Evidence map›Paper›PMID 31760383›Full record

ArticleAging2019

Genome-wide association study of hippocampal atrophy rate in non-demented elders.

Yu Guo, Wei Xu, Jie-Qiong Li, Ya-Nan Ou, Xue-Ning Shen, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Yu

Open access · greenAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
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  4. Cluster Analysis of Cortical Amyloid Burden for Identifying Imaging-driven Subtypes in Mild Cognitive Impairment.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yu GuoDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Jie-Qiong LiDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Ya-Nan OuDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Xue-Ning ShenDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yu-Yuan HuangDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Qiang DongDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Jin-Tai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Qingdao University · CNFudan University · CN

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear. Here we firstly performed a genome-wide association study (GWAS) to identify genetic loci that regulate hippocampal atrophy rate. Six hundred and two non-Hispanic Caucasian elders without dementia were included from the Alzheimer's Disease Neuroimaging Initiative cohort. Three single nucleotide polymorphisms (SNPs) (rs4420638, rs56131196, rs157582) in the

Indexed as

AgedAtrophyCognitive DysfunctionFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMaleMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsPolymorphism, Single NucleotideMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsTOMM40 protein, humancognitive declinegenome-wide association studyhippocampal atrophy rate

Identifiers

PMID31760383
PMCPMC6914394
OpenAlexW2991015858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.