Evidence map›Paper›PMID 31760064›Full record

ArticleToxicology in vitro : an international journal published in association with BIBRA2020

Ongoing inflammation enhances the toxicity of engineered nanomaterials: Application of an in vitro co-culture model of the healthy and inflamed intestine.

Angela A M Kämpfer, Patricia Urbán, Rita La Spina, Isaac Ojea Jiménez, Nilesh Kanase, Vicki Stone, Agnieszka Kinsner-Ovaskainen

Abstract read
In one paragraph

Article in Toxicology in vitro : an international journal published in association with BIBRA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Virulence · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. AI-based nanotoxicity data extraction and prediction of nanotoxicity.Computational and structural biotechnology journal · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Recent Advances in Cell-Based In Vitro Models to Recreate Human Intestinal Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Interactions between Nanoparticles and Intestine.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angela A M KämpferEuropean Commission, Joint Research Centre (JRC), Ispra, Italy; Nano-Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom.
Patricia UrbánEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Rita La SpinaEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Isaac Ojea JiménezEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Nilesh KanaseNano-Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom.
Vicki StoneNano-Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom.
Agnieszka Kinsner-OvaskainenEuropean Commission, Joint Research Centre (JRC), Ispra, Italy. Electronic address: agnieszka.kinsner-ovaskainen@ec.europa.eu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammatory conditions can negatively impact intestinal barrier function and affect the epithelium's interaction with nano-sized materials. We demonstrate the application of a Caco-2/THP-1 co-culture mimicking the intestine in healthy (i.e. stable) or inflamed state in nanotoxicological research. The co-cultures were exposed to non-toxic concentrations of silver nanoparticles (AgNPs) or silver nitrate (AgNO

Indexed as

Caco-2 CellsCoculture TechniquesCytokinesHumansInflammationIntestinesMetal NanoparticlesSilverSilver NitrateTHP-1 CellsCytokinesSilverSilver NitrateCaco-2Inflammatory bowel diseaseIntestinal in vitro co-cultureSilver nanoparticlesTHP-1

Identifiers

PMID31760064
PMCPMC6961208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.