Evidence map›Paper›PMID 31760050›Full record

ArticleJournal of microbiological methods2020

Genotyping Neisseria gonorrhoeae gyrA and penA antimicrobial genes from remnant Neisseria gonorrhoeae positive Cepheid Xpert® clinical specimens - A feasibility study.

S Qadir, O Ellis, E M Keizur, C Stafylis, R Cortado, J D Klausner, Adolescent Trials Network (ATN) CARES Team

Abstract read
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In one paragraph

Article in Journal of microbiological methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S QadirDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: sakinaq786@gmail.com.
O EllisDepartment of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
E M KeizurDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
C StafylisDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
R CortadoDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
J D KlausnerDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: JDKlausner@mednet.ucla.edu.
Adolescent Trials Network (ATN) CARES Team

Funding

Optimizing the HIV Treatment Continuum with a Stepped Care Model for Youth Living with HIVU19HD089886 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FERNANDEZ, MARIA ISABEL, ROTHERAM-BORUS, MARY JANE · 2016 to 2022
$23.4M
Reducing excess broad-spectrum antibiotic use in gonorrheaR21AI117256 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KLAUSNER, JEFFREY DAVID · 2016 to 2017
$424k
NIAID NIH HHS R21 AI117256NICHD NIH HHS U19 HD089886
6 · The paper itself

Abstract

Neisseria gonorrhoeae (NG) has developed resistance to most antibiotics, making it increasingly difficult to treat. Previous studies have predicted antimicrobial NG susceptibility based on the antimicrobial gene target DNA gyrase subunit A (gyrA) codon serine 91 and the penicillin-binding protein 2 (penA) using Roche Cobas® and Hologic APTIMA™ clinical specimens. We studied whether similar methods could be used on remnant NG-positive Cepheid Xpert® specimens.

Indexed as

DNA GyraseDrug Resistance, BacterialFeasibility StudiesFemaleGenotypeGenotyping TechniquesGonorrheaHumansMicrobial Sensitivity TestsNeisseria gonorrhoeaePharynxReal-Time Polymerase Chain ReactionRectumSerine-Type D-Ala-D-Ala CarboxypeptidaseVaginaDNA Gyrasepenicillin-binding protein 2, Neisseria gonorrhoeaeSerine-Type D-Ala-D-Ala CarboxypeptidaseAntibiotic resistanceGenotypinggyrANeisseria gonorrhoeaepenA

Identifiers

PMID31760050
PMCPMC11964821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.