ReviewThe lancet. Psychiatry2020
Mendelian randomisation for nutritional psychiatry.
Review in The lancet. Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review.International journal of epidemiology · 2023Pooled it
- Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study.Asia Pacific journal of clinical nutrition · 2026Article
- Associations between dietary habits and depressive disorder: A diet-wide Mendelian randomization study.Medicine · 2026Article
- Exploring the Role of Skin Microbiota in Autoimmune Skin Diseases from a Bidirectional Mendelian Randomization Perspective.Clinical, cosmetic and investigational dermatology · 2026Article
- Polyunsaturated fatty acids and psychotic disorders: integrating mechanistic, genetic, and clinical evidence.Frontiers in nutrition · 2026Review
- Article
- Nutritional psychiatry for hypertensive older adults.World journal of psychiatry · 2025Article
- Dietary Patterns and Major Depression: Results from 15,262 Participants (International ALIMENTAL Study).Nutrients · 2025Article
- Role of Immune Cells in Mediating the Effect of Lipids on Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Exploring potential causal relationships between gut microbiota, inflammatory factors, and postpartum depression: a Mendelian randomization analysis.BMC pregnancy and childbirth · 2025Article
- Triangulated evidence provides no support for bidirectional causal pathways between diet/physical activity and depression/anxiety.Psychological medicine · 2025Article
- The Relationship between Dietary Habits and Gastroesophageal Reflux Disease: A Two-sample Mendelian Randomization Study.Current medicinal chemistry · 2025Article
- Bone biochemical markers, bone mineral density, and the risk of osteonecrosis of the femoral head: a Mendelian randomization study.BMC musculoskeletal disorders · 2024Article
- Article
- Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study.BMC women's health · 2024Article
- Omega-3 fatty acids and major depression: a Mendelian randomization study.Translational psychiatry · 2024Article
- Causal relationship between genetically determined plasma metabolites and skin cancer: a two-sample Mendelian randomization study.Archives of dermatological research · 2024Article
- Assessing the relationship between gut microbiota and endometriosis: a bidirectional two-sample mendelian randomization analysis.BMC women's health · 2024Article
- The association of smoking on the increased risk of osteoporotic fracture: Results from a cross-sectional study and two-sample Mendelian randomization.Tobacco induced diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the cause of psychiatric ill-health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small effect sizes for individual nutrients. This Personal View considers whether Mendelian randomisation provides a solution to these difficulties, by investigating causality in a low-risk and low-cost way. We reviewed studies using Mendelian randomisation in nutritional psychiatry, along with the potential opportunities and challenges of using this approach for investigating the causal effects of nutritional exposures. Several studies have identified nutritional exposures that are potentially causal by using Mendelian randomisation in psychiatry, offering opportunities for further mechanistic research, intervention development, and replication. The use of Mendelian randomisation as a foundation for intervention development facilitates the best use of resources in an emerging discipline in which opportunities are rich, but resources are often poor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.