Evidence map›Paper›PMID 31759880›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2019

A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).

Hector M González, Wassim Tarraf, Myriam Fornage, Kevin A González, Albert Chai, Marston Youngblood, Maria de Los Angeles Abreu, Donglin Zeng, Sonia Thomas, Gregory A Talavera and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. NeuroEPO plus (NeuralCIMAlzheimer's research & therapy · 2023
    Trial
  4. Novel genetic profile linked to cognitive decline in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  12. APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, La Jolla, CA, USA. Electronic address: hectorgonzalez@ucsd.edu.
Wassim TarrafDepartment of Healthcare Sciences, Wayne State University, Institute of Gerontology, Detroit, MI, USA.
Myriam FornageDepartment of Molecular Medicine and Human Genetics, University of Texas Health Science Center, Houston, TX, USA.
Kevin A GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, La Jolla, CA, USA.
Albert ChaiDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, La Jolla, CA, USA.
Marston YoungbloodDepartment of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA.
Maria de Los Angeles AbreuDepartment of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA.
Donglin ZengDepartment of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA.
Sonia ThomasRTI International, Research Triangle Park, NC, USA.
Gregory A TalaveraDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Robert KaplanAlbert Einstein, College of Medicine, The Bronx, NY, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Martha L DaviglusUniversity of Illinois at Chicago, Institute for Minority Health Research, Chicago, IL, USA.
Neil SchneidermanDepartment of Psychology, University of Miami, Florida, USA.

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN P. ELDER, PAUL E GILBERT · 2018 to 2026
$7.4M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE ConsortiumUH3NS100605 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2018 to 2020
$3.0M
CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control SampleU01AG049505 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2014 to 2017
$3.0M
ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model SystemsU01AG052409 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2016 to 2020
$1.6M
Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR)R21AG056952 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, ALBERTO RAFAEL · 2017 to 2018
$411k
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG059299NIA NIH HHS P30 AG066546NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG048642NIA NIH HHS R01 AG054076NIA NIH HHS R21 AG056952NIA NIH HHS RF1 AG054548NIA NIH HHS RF1 AG061022NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NINDS NIH HHS UH3 NS100605
6 · The paper itself

Abstract

Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay ahead in coming decades. The primary purpose of this Perspectives article was to provide a new research framework for advancing Latino ADRD knowledge, encompassing the unique sociocultural, cardiometabolic, and genomic aspects of Latino health, aging, and ADRD. In addition, we describe some of the research challenges to progress in Latino ADRD research. Finally, we present the Study of Latinos - Investigation of Neurocognitive Aging (SOL-INCA) as an example of implementing this new framework for advancing Latino ADRD research.

Indexed as

Cognitive AgingHealth Services ResearchAlzheimer DiseaseCognitive DysfunctionHispanic or LatinoHumansMiddle AgedNeuropsychological TestsPublic HealthUnited StatesCognitive functionEpidemiologyHispanic/LatinosHispanicsLatinosNeurocognitive functionNeuroepidemiologyNeuropsychologyPopulation neuroscience

Identifiers

PMID31759880
PMCPMC6925624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.