ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Opponent Effects of Hyperarousal and Re-experiencing on Affective Habituation in Posttraumatic Stress Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda.European journal of psychotraumatology · 2022Pooled it
- Differential posttraumatic stress disorder symptom cluster response to stellate ganglion block: secondary analysis of a randomized controlled trial.Translational psychiatry · 2024Trial
- A randomized, controlled trial of alpha-rhythm EEG neurofeedback in posttraumatic stress disorder: A preliminary investigation showing evidence of decreased PTSD symptoms and restored default mode and salience network connectivity using fMRI.NeuroImage. Clinical · 2020Trial
- Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder.NeuroImage. Clinical · 2020Trial
- Mild Traumatic Brain Injury Is Associated with Early Anterior Insula Hyperactivation During Appraisal of Fearful Stimuli in Trauma Survivors with Probable Post-Traumatic Stress Disorder.Brain sciences · 2026Article
- Assessment of PTSD in military personnel via machine learning based on physiological habituation in a virtual immersive environment.Scientific reports · 2025Article
- Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.Current topics in behavioral neurosciences · 2025Review
- Impaired interoception in Colombian victims of armed conflict with PTSD: a preliminary HEP study.Frontiers in psychology · 2025Article
- Does Trauma Change the Way Individuals with Post-Traumatic Stress Disorder (PTSD) Deal with Positive Stimuli?Behavioral sciences (Basel, Switzerland) · 2024Article
- Low-frequency repetitive transcranial magnetic stimulation for the treatment of post-traumatic stress disorder and its comparison with high-frequency stimulation: a systematic review and meta-analysis.Therapeutic advances in psychopharmacology · 2024Article
- Posterior cingulate cortex targeted real-time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default-mode network in PTSD.Brain and behavior · 2023Article
- A longitudinal mediation study of peer victimization and resting-state functional connectivity as predictors of development of adolescent psychopathology.Frontiers in psychiatry · 2023Article
- Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women.Frontiers in psychiatry · 2022Article
- Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit.Frontiers in systems neuroscience · 2022Review
- Disentangling Amygdala Response After Early-Life Trauma: Reactivity, Habituation, and Symptom Profiles.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- The Association between Child and Parent Psychiatric Disorders in Families Exposed to Flood and/or Dioxin.Behavioral sciences (Basel, Switzerland) · 2021Article
- Estradiol Modulates Neural and Behavioral Arousal in Women With Posttraumatic Stress Disorder During a Fear Learning and Extinction Task.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAberrant emotion processing is a hallmark of posttraumatic stress disorder (PTSD), with neurobiological models suggesting both heightened neural reactivity and diminished habituation to aversive stimuli. However, empirical work suggests that these response patterns may be specific to subsets of those with PTSD. This study investigates the unique contributions of PTSD symptom clusters (re-experiencing, avoidance and numbing, and hyperarousal) to neural reactivity and habituation to negative stimuli in combat-exposed veterans.
methodsNinety-five combat-exposed veterans (46 with PTSD) and 53 community volunteers underwent functional magnetic resonance imaging while viewing emotional images. This study examined the relationship between symptom cluster severity and hemodynamic responses to negative compared with neutral images (NEG>NEU).
resultsVeterans exhibited comparable mean and habituation-related responses for NEG>NEU, relative to civilians. However, among veterans, habituation, but not mean response, was differentially related to PTSD symptom severity. Hyperarousal symptoms were related to decreased habituation for NEG>NEU in a network of regions, including superior and inferior frontal gyri, ventromedial prefrontal cortex, superior and middle temporal gyri, and anterior insula. In contrast, re-experiencing symptoms were associated with increased habituation in a similar network. Furthermore, re-experiencing severity was positively related to amygdalar functional connectivity with the left inferior frontal gyrus and dorsal anterior cingulate cortex for NEG>NEU.
conclusionsThese results indicate that hyperarousal symptoms in combat-related PTSD are associated with decreased neural habituation to aversive stimuli. These impairments are partially mitigated in the presence of re-experiencing symptoms, such that during exposure to negative stimuli, re-experiencing symptoms are positively associated with amygdalar connectivity to prefrontal regions implicated in affective suppression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.