Evidence map›Paper›PMID 31759574›Full record

ReviewNeuroimaging clinics of North America2020

Neuroimaging in Schizophrenia.

Matcheri S Keshavan, Guusje Collin, Synthia Guimond, Sinead Kelly, Konasale M Prasad, Paulo Lizano

Open access · greenAbstract readReview
In one paragraph

Review in Neuroimaging clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 138 citations in OpenAlex.

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  20. Current neuropharmacology · 2025
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Matcheri S KeshavanBeth Israel Deaconess Medical Center, Harvard Medical School, 75 Fenwood Road, Boston, MA 02115, USA. Electronic address: keshavanms@gmail.com.
Guusje CollinMcGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, MA 02139, USA; University Medical Center Utrecht Brain Center, Heidelberglaan 100, Postbus 85500, 3508 GA, Utrecht, the Netherlands.
Synthia GuimondDepartment of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada.
Sinead KellyBeth Israel Deaconess Medical Center, Harvard Medical School, 75 Fenwood Road, Boston, MA 02115, USA.
Konasale M PrasadUniversity of Pittsburgh School of Medicine, Suite 279, 3811 O'Hara St, Pittsburgh, PA 15213, USA; Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Paulo LizanoBeth Israel Deaconess Medical Center, Harvard Medical School, 75 Fenwood Road, Boston, MA 02115, USA.
Beth Israel Deaconess Medical Center · USHarvard University · USUniversity Medical Center Utrecht · NLUniversity of Ottawa · CAUniversity of Pittsburgh · US

Funding

Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Synaptic Pruning and Complement Gene in Schizophrenia: Imaging & Cellular StudiesR01MH115026 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PRASAD, KONASALE M · 2018 to 2022
$3.1M
Brain Imaging, Cognitive Enhancement and Early SchizophreniaR01MH092440 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KESHAVAN, MATCHERI S. · 2012 to 2016
$3.1M
Brain Maturation and Vulnerability to SchizophreniaR01MH064023 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KESHAVAN, MATCHERI S. · 2003 to 2008
$3.0M
Rehabilitation, Brain Function and Early SchizophreniaR01MH060902 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KESHAVAN, MATCHERI S. · 2001 to 2005
$2.7M
Dimensional outcomes and neural circuitry associated with psychosis riskR01MH112584 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PRASAD, KONASALE M · 2018 to 2021
$2.1M
4/6 Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096942 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KESHAVAN, MATCHERI S. · 2013 to 2015
$783k
NIMH NIH HHS R01 MH060902NIMH NIH HHS R01 MH064023NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH092440NIMH NIH HHS R01 MH096942NIMH NIH HHS R01 MH112584NIMH NIH HHS R01 MH115026
6 · The paper itself

Abstract

Schizophrenia is a chronic psychotic disorder with a lifetime prevalence of about 1%. Onset is typically in adolescence or early adulthood; characteristic symptoms include positive symptoms, negative symptoms, and impairments in cognition. Neuroimaging studies have shown substantive evidence of brain structural, functional, and neurochemical alterations that are more pronounced in the association cortex and subcortical regions. These abnormalities are not sufficiently specific to be of diagnostic value, but there may be a role for imaging techniques to provide predictions of outcome. Incorporating multimodal imaging datasets using machine learning approaches may offer better diagnostic and predictive value in schizophrenia.

Indexed as

BrainCerebral CortexHumansMagnetic Resonance ImagingMultimodal ImagingNeuroimagingPrognosisSchizophreniaDiagnosisDiffusionFunctionalMagnetic resonance imagingPsychoradiologySchizophreniaSpectroscopyStructural

Identifiers

PMID31759574
PMCPMC7724147
OpenAlexW2984928487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.