Evidence map›Paper›PMID 31759333›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression.

Jennifer L Phillips, Sandhaya Norris, Jeanne Talbot, Taylor Hatchard, Abigail Ortiz, Meagan Birmingham, Olabisi Owoeye, Lisa A Batten, Pierre Blier

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06165848 (Effects Of Different Anesthesia Applications On Mood, Depression, And Anxiety Levels In Burn Patients), which is not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06165848 completednot on this map

Effects Of Different Anesthesia Applications On Mood, Depression, And Anxiety Levels In Burn Patients

Typeobservational_patient_registrySponsorT.C. Sağlık Bakanlığı Ankara Bilkent Şehir HastanesiRan2020 to 2021Enrolled67ConditionsBurn Unspecified Degree, Deep Sedation
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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  17. Combinatorial targeting of NMDARs and 5-HTAlzheimer's research & therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jennifer L PhillipsMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada. Jennifer.Phillips@theroyal.ca.
Sandhaya NorrisMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
Jeanne TalbotMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
Taylor HatchardMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
Abigail OrtizMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0001-6886-767X
Meagan BirminghamMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
Olabisi OwoeyeMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
Lisa A BattenMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
Pierre BlierMood Disorders Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
University of Ottawa · CARoyal Ottawa Mental Health Centre · CA

Funding

CIHR
6 · The paper itself

Abstract

Repeated administration of subanesthetic intravenous ketamine may prolong the rapid decrease in suicidal ideation (SI) elicited by single infusions. The purpose of this secondary analysis was to evaluate reduction in SI with a single ketamine infusion compared with an active control, and prolonged suppression of SI with repeated and maintenance infusions. Thirty-seven participants with treatment-resistant depression (TRD) and baseline SI first received a single ketamine infusion during a randomized, double-blind crossover with midazolam. Following relapse of depressive symptoms, participants received six open-label ketamine infusions administered thrice-weekly over 2 weeks. Antidepressant responders (≥50% decrease in Montgomery-Åsberg Depression Rating Scale [MADRS] scores) received four further open-label infusions administered once-weekly. Changes in SI were assessed with the suicide items on the MADRS (item 10, MADRS-SI) and the Quick Inventory of Depressive Symptomatology-Self Report (item 12, QIDS-SI). Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83). Participants had cumulative reductions in MADRS-SI scores with repeated infusions (P < 0.001), and no further change with maintenance infusions (P = 0.94). QIDS-SI results were consistent with MADRS-SI. Overall, 69% of participants had a complete alleviation of SI following repeated infusions. In TRD, single and repeated ketamine infusions resulted in decreases in SI which were maintained with once-weekly maintenance infusions. This study adds to the growing body of research suggesting ketamine as a possible novel treatment strategy for SI in mood disorders.

Indexed as

Suicidal IdeationAdultAnesthetics, DissociativeDepressive Disorder, Treatment-ResistantDouble-Blind MethodDrug Administration ScheduleFemaleHumansInfusions, IntravenousKetamineMaleMiddle AgedAnesthetics, DissociativeKetamine

Identifiers

PMID31759333
PMCPMC7021716
OpenAlexW2990600117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.