ArticleRespiratory medicine2020
Factors influencing decline in quality of life in smokers without airflow obstruction: The COPDGene study.
Article in Respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Pooled it
- Article
- Regional pulmonary function testing: a new tool for screening subjects with preserved ratio impaired spirometry?ERJ open research · 2025Article
- Nomogram to predict progression from preserved ratio impaired spirometry to chronic obstructive pulmonary disease.Scientific reports · 2025Article
- Causal association between cigarette smoking and the prevalence of preserved ratio impaired spirometry (PRISm), and the progression risk factors of PRISm: A study based on Mendelian randomization and meta-analysis.Tobacco induced diseases · 2025Article
- Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study.International journal of chronic obstructive pulmonary disease · 2025Observational
- Electrical impedance tomography reveals regional lung dysfunction in adults with preserved ratio impaired spirometry: an observational cross-sectional study.Frontiers in medicine · 2025Article
- Influencing factors of good quality of life among chronic obstructive pulmonary disease patients living in Zhejiang Province, China.Scientific reports · 2024Article
- Clinical Characteristics and Medical Utilization of Smokers with Preserved Ratio Impaired Spirometry.International journal of chronic obstructive pulmonary disease · 2023Article
- Chronic obstructive pulmonary disease patients' quality of life and its related factors: A cross-sectional study of the Jordanian population.F1000Research · 2022Article
- Physical performance in relation to preserved ratio impaired spirometry: a cross-sectional study of community-dwelling older Japanese adults.Scientific reports · 2021Article
- Prevalence and Characteristics of Individuals with Preserved Ratio Impaired Spirometry (PRISm) and/or Impaired Lung Function in Japan: The OCEAN Study.International journal of chronic obstructive pulmonary diseaseObservational
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
introductionCurrent and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respiratory exacerbations on QoL in these groups is unknown. We hypothesized that exacerbations and change in exacerbation status would predict QoL decline among normal spirometry and PRISm participants in COPDGene.
methodsCOPDGene is a multicenter, longitudinal study in the U.S. designed to identify genetic determinants of COPD. We enrolled study subjects in Phase 1 of COPDGene and performed multivariable logistic regression models to determine independent predictors of decline in quality of life [>4 points on the St George's Respiratory Questionnaire (SGRQ)]. Separate analyses were performed for current and former smokers with normal spirometry and PRISm. Frequent exacerbator status was defined by > 2 moderate or >1 severe exacerbations in the year prior to the baseline and year 5 follow-up visits.
resultsIndependent predictors of QoL deterioration included current smoking, higher exacerbation frequency, and a change from infrequent to frequent exacerbation status (REF: infrequent to infrequent exacerbation status) in both groups [PRISm (OR = 3.15,95%CI, 1.67-5.94), normal spirometry (OR = 4.72,95%CI, 3.25-6.86)]. A change from frequent to infrequent exacerbation status did not lower the odds of QoL decline in either cohort.
conclusionContinued smoking and the onset of frequent exacerbations were predictors of QoL decline in smokers with normal spirometry and PRISm. Further studies are needed to identify modifiable factors associated with decline in QoL in smokers.
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Registered trials
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