Evidence map›Paper›PMID 31759247›Full record

ArticleRedox biology2020

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.

Sofia-Iris Bibli, Jiong Hu, Matthias S Leisegang, Janina Wittig, Sven Zukunft, Andrea Kapasakalidi, Beate Fisslthaler, Diamantis Tsilimigras, Georgios Zografos, Konstantinos Filis and 4 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
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  6. Posttranslational Regulation of Mammalian Sulfur Amino Acid Metabolism.International journal of molecular sciences · 2025
    Review
  7. Review
  8. The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Review
  9. Article
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  11. Review
  12. Article
  13. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  14. HBiomedicines · 2023
    Article
  15. Article
  16. Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?International journal of molecular sciences · 2022
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Sofia-Iris BibliInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany.
Jiong HuInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany.
Matthias S LeisegangGerman Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany; Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
Janina WittigInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany.
Sven ZukunftInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany.
Andrea KapasakalidiInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.
Beate FisslthalerGerman Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany.
Diamantis TsilimigrasFirst Propedeutic Department of Surgery, Vascular Surgery Division, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Georgios ZografosFirst Propedeutic Department of Surgery, Vascular Surgery Division, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Konstantinos FilisFirst Propedeutic Department of Surgery, Vascular Surgery Division, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Ralf P BrandesGerman Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany; Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
Andreas PapapetropoulosLaboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens Medical School, Athens, Greece; Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, Athens, 11527, Greece.
Fragiska SigalaFirst Propedeutic Department of Surgery, Vascular Surgery Division, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address: fsigala@med.uoa.gr.
Ingrid FlemingInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany. Electronic address: fleming@em.uni-frankfurt.de.
German Centre for Cardiovascular Research · DEGoethe University Frankfurt · DENational and Kapodistrian University of Athens · GRAcademy of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystathionine γ lyase (CSE) is the major source of hydrogen sulfide-derived species (H

Indexed as

Lipid PeroxidationAnimalsCystathionine gamma-LyaseEndothelial CellsGene Expression RegulationHEK293 CellsHumansHuman Umbilical Vein Endothelial CellsHydrogen SulfideKruppel-Like Transcription FactorsMiceMicroRNAsOxidation-ReductionPeroxiredoxin VIPlaque, AtheroscleroticStress, MechanicalCystathionine gamma-LyaseHydrogen SulfideKLF2 protein, humanKruppel-Like Transcription FactorsMicroRNAsMIRN27 microRNA, humanPeroxiredoxin VIPRDX6 protein, human

Identifiers

PMID31759247
PMCPMC6880097
OpenAlexW2986720590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.