Evidence map›Paper›PMID 31758757›Full record

ArticleBirth defects research2020

Dynamic acetylation profile during mammalian neurulation.

Valentina Massa, Laura Avagliano, Paolo Grazioli, Sandra C P De Castro, Chiara Parodi, Dawn Savery, Patrizia Vergani, Serena Cuttin, Patrizia Doi, Gaetano Bulfamante and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Valentina MassaDepartment of Health Sciences, University of Milan, Milan, Italy.ORCID 0000-0003-2246-9515
Laura AvaglianoDepartment of Health Sciences, University of Milan, Milan, Italy.
Paolo GrazioliDepartment of Health Sciences, University of Milan, Milan, Italy.ORCID 0000-0001-9120-4217
Sandra C P De CastroUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Chiara ParodiDepartment of Health Sciences, University of Milan, Milan, Italy.
Dawn SaveryUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Patrizia VerganiDepartment of Obstetrics and Gynaecology, Foundation MBBM, University of Milano-Bicocca, Monza, Italy.
Serena CuttinDepartment of Pathology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Patrizia DoiDepartment of Health Sciences, University of Milan, Milan, Italy.
Gaetano BulfamanteDepartment of Health Sciences, University of Milan, Milan, Italy.
Andrew J CoppUCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-2544-9117
Nicholas D E GreeneUCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-4170-5248
University of Milan · ITUniversity College London · GBUniversity of Milano-Bicocca · IT

Funding

Great Ormond Street Children's CharityMedical Research Council G0802163National Institute for Health Research Biomedical Research CentreUniversità degli Studi di Milano intramural fundsUniversità degli Studi di Milano scholarshipWellcome Trust 087525
6 · The paper itself

Abstract

backgroundNeural tube defects (NTDs) result from failure of neural tube closure during embryogenesis. These severe birth defects of the central nervous system include anencephaly and spina bifida, and affect 0.5-2 per 1,000 pregnancies worldwide in humans. It has been demonstrated that acetylation plays a pivotal role during neural tube closure, as animal models for defective histone acetyltransferase proteins display NTDs. Acetylation represents an important component of the complex network of posttranslational regulatory interactions, suggesting a possible fundamental role during primary neurulation events. This study aimed to assess protein acetylation contribution to early patterning of the central nervous system both in human and murine specimens.

methodsWe used both human and mouse (Cited2

resultsWe report the dynamic profile of histone and protein acetylation status during neural tube closure. We also report a rescue effect in an animal model by chemical p53 inhibition.

conclusionsOur data suggest that the p53-acetylation equilibrium may play a role in primary neurulation in mammals.

Indexed as

AcetylationAnencephalyAnimalsDisease Models, AnimalEmbryonic DevelopmentHistone AcetyltransferasesHumansMammalsMiceNeural Tube DefectsNeurulationRepressor ProteinsSpinal DysraphismTrans-ActivatorsTranscription FactorsTumor Suppressor Protein p53Cited2 protein, mouseHistone AcetyltransferasesRepressor ProteinsTrans-ActivatorsTranscription FactorsTumor Suppressor Protein p53acetylation profileCited2neural tube defectsneurodevelopmentp53

Identifiers

PMID31758757
PMCPMC7004172
OpenAlexW2990533697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.