Evidence map›Paper›PMID 31758701›Full record

ArticleClinical and experimental immunology2020

IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis.

M Abe, D D Rastelli, A C Gomez, E Cingolani, Y Lee, P R Soni, M C Fishbein, T J A Lehman, K Shimada, T R Crother and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Kawasaki Disease-Associated Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

M AbeDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-5641-4996
D D RastelliDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
A C GomezDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-7019-9607
E CingolaniCedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Y LeeDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
P R SoniDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-1948-9224
M C FishbeinDepartment of Pathology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
T J A LehmanDivision of Rheumatology, Department of Pediatrics, Weill Cornell Medical School, New York, NY, USA.
K ShimadaDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-8213-5686
T R CrotherDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-8465-6127
S ChenDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-2919-4967
M Noval RivasDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-5570-8928
M ArditiDivisions of Infectious Diseases and Immunology, Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-9042-2909
Cedars-Sinai Medical Center · USCornell University · USUniversity of California, Los Angeles · US

Funding

Role of IL-1 in Bacterial ligand-induced vasculitis and myocarditisR01AI072726 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2008 to 2020
$4.5M
Role of intestinal microbiome and gut permeability in the development of Kawasaki Disease vasculitisR01HL139766 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Magali Noval Rivas · 2018 to 2026
$3.4M
Innate Immunity and Pathogen mediated Acceleration in Vascular InflammationR01HL111483 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, SHUANG · 2012 to 2016
$2.0M
Role of protein citrullination in innate immunityR21AI133452 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI SHIMADA, KENICHI · 2017 to 2018
$481k
NHLBI NIH HHS R01 HL111483NHLBI NIH HHS R01 HL139766NIAID NIH HHS R01 AI072726NIAID NIH HHS R21 AI133452
6 · The paper itself

Abstract

Kawasaki disease (KD) is the leading cause of acquired heart disease in children. In addition to coronary artery abnormalities, aneurysms and myocarditis, acute KD is also associated with echocardiogram (ECG) abnormalities in 40-80% of patients. Here, we show that these ECG changes are recapitulated in the Lactobacillus casei cell wall extract (LCWE)-induced KD vasculitis mouse model. LCWE-injected mice developed elevated heart rate and decreased R wave amplitude, with significant differences in prolonged ventricular repolarization. LCWE-injected mice developed cardiac ganglion inflammation, that may affect the impulse-conducting system in the myocardium. Furthermore, serum nerve growth factor (NGF) was significantly elevated in LCWE-injected mice, similar to children with KD vasculitis, associated with increased neural remodeling of the myocardium. ECG abnormalities were prevented by blocking interleukin (IL)-1 signaling with anakinra, and the increase in serum NGF and cardiac neural remodeling were similarly blocked in Il1r1

Indexed as

Disease Models, AnimalAnimalsAntirheumatic AgentsBiological ProductsCell WallChildElectrocardiographyFemaleHumansInterleukin-1Interleukin 1 Receptor Antagonist ProteinLacticaseibacillus caseiMice, Inbred C57BLMice, KnockoutMucocutaneous Lymph Node SyndromeNerve Growth FactorAntirheumatic AgentsBiological ProductsInterleukin-1Interleukin 1 Receptor Antagonist ProteinNerve Growth FactorReceptors, Interleukin-1 Type I

Identifiers

PMID31758701
PMCPMC7008220
OpenAlexW2990310039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.