ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2020
Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Grey matter changes on brain MRI in subjective cognitive decline: a systematic review.Alzheimer's research & therapy · 2022Pooled it
- Acupuncture was associated with improved functional connectivity of the left hippocampal perceptual subregion in amnestic mild cognitive impairment.Brain imaging and behavior · 2026Trial
- rTMS modulates precuneus-hippocampal subregion circuit in patients with subjective cognitive decline.Aging · 2020Trial
- Age and sex differences in cognitive performance in people with subjective cognitive decline and associated worry: Findings from the Canadian Longitudinal Study on Aging.Journal of neuropsychology · 2026Article
- Associations between ventricular boundary shift integral and composite cognitive domains across the alzheimer's disease continuum.Scientific reports · 2026Article
- The predictive role of olfactory identification on episodic memory and mild cognitive impairment: Results from the CIMA-Q cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Dynamic Functional Network Connectivity Pattern of the Amygdalohippocampal Complex in Individuals With Subjective Cognitive Decline.Human brain mapping · 2025Article
- Domain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.Heliyon · 2025Article
- Letter to the Editor regarding "Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?"AJNR. American journal of neuroradiology · 2025Article
- Neuronal and glial dysfunction, white matter hyperintensities and cognition in ageing and Alzheimer's disease.Brain communications · 2025Article
- Vascular risk factor associations with subjective cognitive decline and mild behavioural impairment.Brain communications · 2025Article
- White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease.Frontiers in neuroscience · 2024Article
- Clinically feasible automated MRI volumetry of the brain as a prognostic marker in subjective and mild cognitive impairment.Frontiers in neurology · 2024Article
- The assessment of executive function abilities in healthy and neurodegenerative aging-A selective literature review.Frontiers in aging neuroscience · 2024Review
- The relationship between learning slopes and Alzheimer's Disease biomarkers in cognitively unimpaired participants with and without subjective memory concerns.Journal of clinical and experimental neuropsychology · 2023Article
- The use of hippocampal grading as a biomarker for preclinical and prodromal Alzheimer's disease.Human brain mapping · 2023Article
- Quantitative morphometric changes in vascular mild cognitive impairment patients: early diagnosis of dementia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- White matter hyperintensity load varies depending on subjective cognitive decline criteria.GeroScience · 2023Article
- The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer's Disease in Subjective Cognitive Decline.Journal of Alzheimer's disease reports · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveThe concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer's disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals.
methodWe included 126 participants from the Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).
resultsSignificant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups. DISCUSSION: As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD's hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.
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