SynthesisPhysiological reports2019
Impact of parental exercise on epigenetic modifications inherited by offspring: A systematic review.
Synthesis in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The Influence of Epigenetic Modifications on Metabolic Changes in White Adipose Tissue and Liver and Their Potential Impact in Exercise.Frontiers in physiology · 2021Pooled it
- Impact of parental exercise on epigenetic modifications inherited by offspring: A systematic review.Physiological reports · 2019Pooled it
- Physical Activity During the Perinatal Period: A Fact Sheet for Clinicians.American journal of lifestyle medicine · 2026Review
- Maternal exercise enhances hippocampal plasticity and resilience against stress-induced depressive behaviors in adult offspring.Scientific reports · 2026Article
- Exercise-Induced Molecular Adaptations in Chronic Non-Communicable Diseases-Narrative Review.International journal of molecular sciences · 2025Review
- Epigenetic modulation by life-style: advances in diet, exercise, and mindfulness for disease prevention and health optimization.Frontiers in nutrition · 2025Review
- Paternal peri-conceptional physical activity and the risk of congenital heart disease in offspring: A case-control study.Andrology · 2025Observational
- Exercise Is Medicine: How Do We Implement It?Nutrients · 2023Article
- A Review on Epigenetic Inheritance of Experiences in Humans.Biochemical genetics · 2022Review
- Interactions between Muscle and Bone-Where Physics Meets Biology.Biomolecules · 2020Review
- Optimal Human Functioning Requires Exercise Across the Lifespan: Mobility in a 1g Environment Is Intrinsic to the Integrity of Multiple Biological Systems.Frontiers in physiology · 2020Review
- Understanding Barriers and Facilitators to Physical Activity Engagement to Inform a Precision Prescription Approach during Pregnancy.American journal of lifestyle medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Performing regular exercise is associated with numerous health benefits including a reduction in all-cause mortality. The mechanisms associated with exercise-induced health improvements are wide ranging and benefit virtually every organ system in the body. Of significance, recent evidence has suggested that some of these protective benefits may also be passed to offspring through multiple generations via alterations in gamete presentation, changes to the in-utero and offspring rearing environments, and epigenetic modifications. The purpose of this review was to systematically examine the current literature for evidence of exercise-induced epigenetic modifications in offspring. A systematic search yielded four papers that met inclusion criteria. Parental exercise interventions were associated with differential DNA methylation patterns in offspring. These shifts in methylation patterns were consistent with concurrent changes in offspring mRNA levels, protein expression, and functional measures. Many of the observed changes were related to metabolic pathways. Hence, the evidence suggests that exercise-induced epigenetic changes can be observed in offspring and may play a pivotal role among the multifactorial intergenerational-health impact of exercise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.