Evidence map›Paper›PMID 31758655›Full record

ArticleCancer medicine2020

Silencing circular RNA VANGL1 inhibits progression of bladder cancer by regulating miR-1184/IGFBP2 axis.

Dengke Yang, Haining Qian, Zhen Fang, An Xu, Shutian Zhao, Bingyan Liu, Dong Li

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dengke YangDepartment of Urinary Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Haining QianDepartment of Urinary Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhen FangDepartment of Urinary Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
An XuDepartment of Urinary Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shutian ZhaoDepartment of Urinary Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Bingyan LiuDepartment of Interventional Radiology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Dong LiDepartment of Urinary Surgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0002-2495-6862
Tongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA VANGL1 (circVANGL1) is generated from two exons of the Van Gogh-like 1 (VANGL1) gene and serves as a tumor promoter by sponging certain microRNAs (miRNAs). However, the role of circVANGL1 in bladder cancer (BC) is still unclear. So, in order to investigate the role of circVANGL1 in BC, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was employed to evaluate the circVANGL1 expression in tumor tissues from BC patients and in BC cell lines. Small interfering RNA against circVANGL1 was constructed and stably transfected into human bladder epithelium immortalized cells (SV-HUC). Cell invasion and migration were detected in Transwell chambers, cell proliferation was determined by CCK8 assays, and tumorigenesis in nude mice was examined to assess the effect of circVANGL1 in BC. Subcellular localization of circVANGL1 was confirmed by fluorescence in situ hybridization. The interactive relationships among circVANGL1, miRNA, and relative proteins were confirmed by luciferase reporter assays. The results showed that circVANGL1 was upregulated in both BC tissues and cell lines. Silencing the expression of circVANGL1 suppressed cell invasion, migration, and proliferation during in vitro experiments. Mechanistically, we demonstrated that circVANGL1 upregulated the expression of miR-1184 target gene insulin-like growth factor-binding protein 2 (IGFBP2) by sponging miR-1184, which promoted the aggressive biological behaviors of BC. Taken together, our results indicate that circVANGL1 acts as a tumor promoter through the novel circVANGL1/miR-1184/IGFBP2 axis. Hopefully, our study will provide new ideas for the clinical treatment of BC.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisBiomarkers, TumorCarrier ProteinsCell ProliferationHumansInsulin-Like Growth Factor Binding Protein 3Membrane ProteinsMiceMice, Inbred BALB CMice, NudeMicroRNAsPrognosisRNA, CircularTumor Cells, CulturedBiomarkers, TumorCarrier ProteinsIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Membrane ProteinsMicroRNAsMIRN1184 microRNA, humanRNA, CircularVANGL1 protein, humanmetastasismicroenvironmentsignal transduction

Identifiers

PMID31758655
PMCPMC6970048
OpenAlexW2989713875

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.