ArticleIrish journal of medical science2020
Evaluation of simple inflammatory blood parameters in patients with migraine.
Article in Irish journal of medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Systemic Inflammation Markers in Migraine: A Cross-Sectional Study.European journal of neurology · 2026Article
- A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocyte-Platelet Score in Migraine.Journal of inflammation research · 2026Article
- Association between serum high-sensitivity C-reactive protein levels and migraine: a REFORM study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse Headache: A Cross-sectional Study.Brain and behavior · 2025Article
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- A study of changes in hematologic parameters in patients with migraine.Clinical and experimental immunology · 2025Article
- Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?The journal of headache and pain · 2025Article
- A Review of the Biochemical Diagnostic Biomarkers in Migraine: New Perspectives in Diagnostics.Pain research & management · 2025Review
- Oxidative Stress and Migraine.Molecular neurobiology · 2024Review
- Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies.Diagnostics (Basel, Switzerland) · 2024Article
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- The Association between Serum Total Bilirubin and Severe Headaches or Migraine in American Adults.Current neurovascular research · 2024Article
- No association between blood-based markers of immune system and migraine status: a population-based cohort study.BMC neurology · 2023Article
- Identifying causal genes for migraine by integrating the proteome and transcriptome.The journal of headache and pain · 2023Article
- Decreased Serum Uric Acid Level as an Indicator of Altered Oxidative Balance in Patients With Migraine.Cureus · 2022Article
- Role of Peripheral Inflammatory Markers in Patients with Acute Headache Attack to Differentiate between Migraine and Non-Migraine Headache.Journal of clinical medicine · 2022Article
- Evaluation of simple antioxidant blood parameters in patients with migraine.Frontiers in neurology · 2022Article
- Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients.Journal of neurosciences in rural practice · 2021Article
- Evaluation of serum uric levels in migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Incidence, Risk Factors and Outcomes of Postoperative Headache After Stanford Type a Acute Aortic Dissection Surgery.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
aimThis study aimed to identify the serum neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), and C-reactive protein (CRP)/albumin (CAR) ratios among patients with diagnosis of migraine according to migraine subtypes (attack/attack-free period, migraine with or without aura, episodic/chronic migraine, family history/no family history) and to collect data to investigate the role of inflammation and oxidative stress in etiology.
methodThe study was completed with 235 patients with migraine diagnosis classified according to the International Classification of Headache Disorders-2013(ICHD) classification and 166 healthy controls. Patients with migraine were assessed during the attack by emergency medicine specialists in the emergency room and in attack-free periods in neurology clinics by neurology specialists.
resultsOf patients with migraine, 77.02% were female and 22.98% were male. The neutrophil, NLR, PLR, and MLR levels were higher than the control group (p < 0.05). The serum CRP, neutrophil, NLR, MLR, and CAR levels were higher, and albumin and lymphocyte levels were lower during migraine attack periods (p < 0.05). Migraines with aura were observed to have higher serum NLR levels compared to the aura-free patients (p < 0.05). Migraine patients with positive family history were found to have higher NLR levels compared to patients without a family history (p < 0.05).
conclusionAlthough non-specific, serum NLR, MLR, PLR, and CAR levels may be potential biomarkers associated with migraine subtypes with different clinical features such as migraine attack period, migraine with aura, and patients with family history of migraine. Elevated inflammatory markers may indicate the severity of disease.
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