Evidence map›Paper›PMID 31758514›Full record

ArticleJournal of assisted reproduction and genetics2020

Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone.

Stine Aagaard Lunding, Susanne Elisabeth Pors, Stine Gry Kristensen, Jane Alrø Bøtkjær, Maja Ramløse, Janni Vikkelsø Jeppesen, Esben Meulengracht Flachs, Anja Pinborg, Kirsten Tryde Macklon, Anette Tønnes Pedersen and 2 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Closing the knowledge void between healthy gametes and healthy offspring.Journal of assisted reproduction and genetics · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Stine Aagaard LundingThe Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. stine.aagaard.lunding@regionh.dk.ORCID http://orcid.org/0000-0003-4899-7420
Susanne Elisabeth PorsLaboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Stine Gry KristensenLaboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jane Alrø BøtkjærLaboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Maja RamløseLaboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Janni Vikkelsø JeppesenThe Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Esben Meulengracht FlachsDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
Anja PinborgThe Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Kirsten Tryde MacklonThe Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Anette Tønnes PedersenThe Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Claus Yding AndersenLaboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Anders Nyboe AndersenThe Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Copenhagen University Hospital · DKBispebjerg Hospital · DKHvidovre Hospital · DK

Funding

ReproUnion 20200407
6 · The paper itself

Abstract

purposeTo evaluate the association between anti-Müllerian hormone (AMH) and follicle density in infertile women with diminished ovarian reserve (DOR) versus women with normal ovarian reserve?

methodsCase-control study comparing follicle densities in ovarian cortex from 20 infertile women with DOR (AMH ≤ 5 pmol/L) and 100 controls with presumed normal ovarian reserve.

resultsFor all women > 25 years, the follicle densities correlated positively with AMH levels. For each single picomole per liter increase in AMH the follicle density increased by 6% (95% CI 3.3-8.5%) when adjusted for age. This was similar for women with DOR and controls. The follicle density was 1.8 follicles/mm

conclusionsFollicle density and AMH concentrations correlate also when AMH is low. However, AMH is only a reliable marker for the true ovarian reserve when age is included in the estimation and women with DOR may have more follicles than their AMH levels imply.

Indexed as

Ovarian ReserveAdultAge FactorsAnti-Mullerian HormoneCase-Control StudiesFemaleHumansInfertility, FemaleOvarian FollicleAnti-Mullerian HormoneAMHDiminished ovarian reserveFollicle densityOvarian biopsy

Identifiers

PMID31758514
PMCPMC7000582
OpenAlexW2991428302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.