ArticleJournal of industrial microbiology & biotechnology2020
Apc.LaeA and Apc.VeA of the velvet complex govern secondary metabolism and morphological development in the echinocandin-producing fungus Aspergillus pachycristatus.
Article in Journal of industrial microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Article
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- Regulation ofToxins · 2025Article
- Engineering of Global Transcriptional Regulators (GTRs) inJournal of fungi (Basel, Switzerland) · 2025Review
- Elucidating the mechanisms of echinocandin B biosynthesis under fatty acid feeding in3 Biotech · 2025Article
- UvVelC is important for conidiation and pathogenicity in the rice false smut pathogenVirulence · 2024Article
- Gene expression screening and cell factory engineering for enhancing echinocandin B production in Aspergillus nidulans NRRL8112.Microbial cell factories · 2024Article
- Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites.Journal of fungi (Basel, Switzerland) · 2024Review
- PrJournal of fungi (Basel, Switzerland) · 2023Article
- AfLaeA, a Global Regulator of Mycelial Growth, Chlamydospore Production, Pathogenicity, Secondary Metabolism, and Energy Metabolism in the Nematode-Trapping FungusMicrobiology spectrum · 2023Article
- Investigation of the enhancement for Echinocandin B fermentation with methyl oleate from transcription level.Bioprocess and biosystems engineering · 2023Article
- Article
- Itaconic acid production is regulated by LaeA inMetabolic engineering communications · 2022Article
- Identification of a Novel Pleiotropic Transcriptional Regulator Involved in Sporulation and Secondary Metabolism Production inInternational journal of molecular sciences · 2022Article
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- The regulation of BbLaeA on the production of beauvericin and bassiatin in Beauveria bassiana.World journal of microbiology & biotechnology · 2021Article
- The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans.Journal of microbiology (Seoul, Korea) · 2021Article
- Identification of Secondary Metabolites fromMolecules (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of the global secondary metabolite regulators LaeA and VeA on echinocandin B production and morphological development was evaluated in the industrial production strain Aspergillus pachycristatus NRRL 11440. Other representative secondary metabolites were examined as well to determine if the velvet complex functions as in A. nidulans and other species of fungi. Genetic methods used for gene manipulations in A. nidulans were applied to A. pachycristatus. Separate deletions of genes Apc.laeA and Apc.veA resulted in similar yet differing phenotypes in strain NRRL 11440. Disruption of Apc.laeA and Apc.veA significantly reduced, but did not eliminate, the production of echinocandin B. Similar to what has been observed in A. nidulans, the production of sterigmatocystin was nearly eliminated in both mutants. Quantitative reverse transcription PCR analyses confirmed that selected genes of both the echinocandin B and sterigmatocystin gene clusters were down-regulated in both mutant types. The two mutants differed with respect to growth of aerial hyphae, pigmentation, development of conidiophores, conidial germination rate, and ascospore maturation. Further functional annotation of key regulatory genes in A. pachycristatus and related Aspergillus species will improve our understanding of regulation of echinocandin production and co-produced metabolites.
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