Evidence map›Paper›PMID 31758413›Full record

ArticleJournal of industrial microbiology & biotechnology2020

Metabolic transcriptional analysis on copper tolerance in moderate thermophilic bioleaching microorganism Acidithiobacillus caldus.

Shoushuai Feng, Shaoxiang Hou, Yaquan Cui, Yanjun Tong, Hailin Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Cadmium stress triggers significant metabolic reprogramming inComputational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shoushuai FengSchool of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, People's Republic of China.
Shaoxiang HouSchool of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, People's Republic of China.
Yaquan CuiSchool of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, People's Republic of China.
Yanjun TongState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China. tongyanjun@jiangnan.edu.cn.
Hailin YangSchool of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, People's Republic of China. fengshuaihaha@126.com.
Jiangnan University · CNMinistry of Education of the People's Republic of China · CN

Funding

China Postdoctoral Science Foundation 2016M601716national first-class discipline program of Light Industry Technology and Engineering LITE2018-23National Natural Science Foundation of China No. 21606110National Natural Science Foundation of China No. 21776113National Natural Science Foundation of China No. 21878128National Natural Science Foundation of China No. 31701582the Fundamental Research Funds for the Central Universities No. 2050205the funding of Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education KLCCB-KF201907the funding of Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education KLCCB-KF201909the funding of Key Laboratory of Industrial Biotechnology, Ministry of Education KLIB-KF201903the funding of Key Laboratory of Industrial Biotechnology, Ministry of Education KLIB-KF201906the Priority Academic Program Development of Jiangsu Higher Education Institutions, and Program of Introducing Talents of Discipline to Universities No. 111-2-06the Social Development Projects of Jiangsu Province BE2017625
6 · The paper itself

Abstract

Bioleaching, an alternative environmental smelting technology, typically uses high concentrations of heavy metal ions, especially in the subsequent phase, due to metal ion accumulation from the mineral. In this study, we analyzed the overall response of the bioleaching microorganism Acidithiobacillus caldus to copper stress through physiological and transcriptomic analyses. Scanning electron microscopy results showed higher extracellular polymeric substances secretion and cell aggregation under copper stress. Intracellular levels of glutamic acid, glycine and cysteine increased, favoring the synthesis of glutathione for maintenance of the oxidation-reduction state. GSH, during copper stress conditions, the activity of GSH-PX and CAT increased, resulting in reduced oxidative damage while maintaining stable intracellular pH. Higher unsaturated and cyclopropane fatty acid levels resulted in increased membrane fluidity and compactness and decreased ATP levels to support the energy requirements for stress resistance. Initially, H

Indexed as

AcidithiobacillusCopperCysteineGene Expression ProfilingMetabolic Networks and PathwaysOxidation-ReductionSulfatesCopperCysteineSulfatesA. caldusCopper stressqRT-PCRRNA-SeqTranscriptome

Identifiers

PMID31758413
OpenAlexW2990346155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.