Evidence map›Paper›PMID 31758326›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial.

Julie Ryan Wolf, Jennifer S Gewandter, Javier Bautista, Charles E Heckler, Jon Strasser, Pawal Dyk, Thomas Anderson, Howard Gross, Tod Speer, Lindsey Dolohanty and 3 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 8 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 8 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The validity of over-the-counter skin, hair, and nail recommendations for adult patients with cancer: A systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Pooled it
  5. Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Review
  11. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Photobiomodulation therapy for mitigating severity of radiodermatitis in cancer patients undergoing radiotherapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  16. Evolution of radiation-induced dermatitis treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  17. The Promising Role of Polyphenols in Skin Disorders.Molecules (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Julie Ryan WolfDepartment of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 697, Rochester, NY, 14642, USA. julie_ryan@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-0592-7820
Jennifer S GewandterDepartment of Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA.
Javier BautistaURCC NCORP Research Base, University of Rochester Medical Center, Rochester, NY, USA.
Charles E HecklerURCC NCORP Research Base, University of Rochester Medical Center, Rochester, NY, USA.
Jon StrasserDelaware/Christiana Care NCORP, Newark, DE, USA.
Pawal DykHeartland Cancer Research NCORP, St. Louis, MO, USA.
Thomas AndersonColumbus NCORP, Columbus, OH, USA.
Howard GrossDayton Clinical Oncology Program, Dayton, OH, USA.
Tod SpeerMetro-Minnesota NCORP, St. Louis Park, MN, USA.
Lindsey DolohantyDepartment of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 697, Rochester, NY, 14642, USA.
Kevin BylundDepartment Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA.
Alice P PentlandDepartment of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 697, Rochester, NY, 14642, USA.
Gary R MorrowURCC NCORP Research Base, University of Rochester Medical Center, Rochester, NY, USA.
University of Rochester Medical Center · USChristiana Care Health System · USColumbus Center · USDayton Clinical Oncology Program · USHeartland Cancer Research · USMetro-Minnesota Community Oncology Research Consortium · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Effectiveness of Prophylactic Topical Treatments for Radiation DermatitisR21CA178648 · NCI · UNIVERSITY OF ROCHESTER · PI WOLF, JULIE RYAN · 2014 to 2015
$367k
NCI NIH HHS 1R21CA178648-01A1NCI NIH HHS R21 CA178648NCI NIH HHS UG1 CA189961NCI NIH HHS UG1CA189961
6 · The paper itself

Abstract

purposeAlthough topical agents are often provided during radiation therapy, there is limited consensus and evidence for their use prophylactically to prevent or reduce radiation dermatitis.

methodsThis was a multi-site, randomized, placebo-controlled, blinded study of 191 breast cancer patients to compare the prophylactic effectiveness of three topical agents (Curcumin, HPR Plus™, and Placebo) for reducing radiation dermatitis and associated pain. Patients applied the topical agent to their skin in the radiation area site three times daily starting the first day of radiation therapy (RT) until 1 week after RT completion.

resultsOf the 191 randomized patients, 171 patients were included in the final analyses (87.5% white females, mean age = 58 (range = 36-88)). Mean radiation dermatitis severity (RDS) scores did not significantly differ between study arms (Curcumin = 2.68 [2.49, 2.86]; HPR Plus™ = 2.64 [2.45, 2.82]; Placebo = 2.63 [2.44, 2.83]; p = 0.929). Logistic regression analyses showed that increased breast field separation positively correlated with increased radiation dermatitis severity (p = 0.018). In patients with high breast field separation (≥ 25 cm), RDS scores (Curcumin = 2.70 [2.21, 3.19]; HPR Plus™ = 3.57 [3.16, 4.00]; Placebo = 2.95 [2.60, 3.30]; p = 0.024) and pain scores (Curcumin = 0.52 [- 0.28, 1.33]; HPR Plus™ = 0.55 [- 0.19, 1.30]; Placebo = 1.73 [0.97, 2.50]; p = 0.046) significantly differed at the end of RT.

conclusionsAlthough there were no significant effects of the treatment groups on the overall population, our exploratory subgroup analysis suggests that prophylactic treatment with topical curcumin may be effective for minimizing skin reactions and pain for patients with high breast separation (≥ 25 cm) who may have the worst skin reactions.

Indexed as

Administration, TopicalAdultAgedAged, 80 and overFemaleHumansMiddle AgedPainRadiodermatitisBreast cancerPainRadiation dermatitisRadiation therapy

Identifiers

PMID31758326
PMCPMC7242117
OpenAlexW2991023029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.