Evidence map›Paper›PMID 31758289›Full record

ArticleClinical & experimental metastasis2020

Ovarian, uterine, and cervical cancer patients with distant metastases at diagnosis: most common locations and outcomes.

Austin B Gardner, Lindsey M Charo, Amandeep K Mann, Daniel S Kapp, Ramez N Eskander, John K Chan

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical & experimental metastasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Molecular medicine reports · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Austin B GardnerUniversity of California, Irvine School of Medicine, Irvine, CA, USA.
Lindsey M CharoUCSD Rebecca and John Moores Cancer Center, La Jolla, CA, USA.
Amandeep K MannPalo Alto Medical Foundation Research Institute, Palo Alto, CA, USA.
Daniel S KappStanford University School of Medicine, Stanford, CA, USA.
Ramez N EskanderUCSD Rebecca and John Moores Cancer Center, La Jolla, CA, USA.
John K ChanCalifornia Pacific & Palo Alto Medical Foundation/Sutter Health Research Institute, San Francisco, CA, USA. chanjohn@sutterhealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine the location patterns of distant metastases at initial staging and outcomes of ovarian, uterine, and cervical cancer patients. Data were obtained from the SEER database from 2010 to 2015. Analyses were performed using Kaplan-Meier and multivariate Cox proportional hazard methods. Of 3035 patients (median age: 63, range: 17-95) with stage IV gynecologic cancer, ovarian, uterine, and cervical cancers were present in 42%, 40%, and 18% of the cohort. The proportion of lung, liver, bone and brain metastases were identified in 38%, 57%, 4%, and 1% of ovarian cancer patients, 62%, 22%, 13%, and 3% of uterine cancer patients, and 59%, 16%, 23%, and 2% of cervical cancer patients, respectively. The 5-year disease-specific survival for all patients was 19%. Those with liver metastases had survival rates of 26% compared to 15% for lung, 13% for bone, and 6% for brain (p < 0.0001). Patients with ovarian, uterine, and cervical cancers had survival rates of 28%, 12%, and 12%, respectively (p < 0.0001). On multivariate analysis, brain metastasis (HR = 1.64, 95% CI 1.21-2.22, p < 0.01), uterine (HR = 1.77, 95 CI 1.56-2.02, p < 0.0001) and cervical (HR = 1.35, 95% CI 1.11-1.63, p < 0.01) cancers, and lack of insurance (HR = 1.41, 95% CI 1.16-1.73, p < 0.001) were independent predictors for poorer survival. Age, year, region, and race did not affect prognosis. Stage IV ovarian cancer most frequently metastasizes to the liver, whereas uterine and cervical cancers spread more to the lung. Overall, these patients have poor prognosis, particularly those with uterine or cervical primary disease or brain metastases.

Indexed as

AdolescentAdultAgedAged, 80 and overBrain NeoplasmsFemaleHumansKaplan-Meier EstimateLiver NeoplasmsLung NeoplasmsLymphatic MetastasisMiddle AgedNeoplasm StagingOvarian NeoplasmsPrognosisRetrospective StudiesCervical cancerDistant metastasesGynecologic cancersMetastasisOvarian cancerUterine cancer

Identifiers

PMID31758289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.