ArticleInternational journal of clinical oncology2020
The impact of postoperative inflammation on recurrence in patients with colorectal cancer.
Article in International journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Exercise intervention for post-treatment colorectal cancer survivors: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2020Pooled it
- Clinical significance of the C-reactive protein-albumin-lymphocyte index in older patients with colorectal cancer.Surgery today · 2026Article
- Article
- Combined prophylactic negative-pressure wound therapy and preoperative oral antibiotics reduce perineal wound complications after abdominoperineal resection.Surgery today · 2026Article
- The Prognostic Role of Postoperative Inflammation After Minimally Invasive Resection for Colorectal Cancer.Annals of surgical oncology · 2026Article
- Prognostic significance of postoperative serum C-reactive protein levels after minimally invasive esophagectomy for esophageal cancer.General thoracic and cardiovascular surgery · 2026Article
- Comparative outcomes of laparoscopic and robotic anterior rectal resection for cM0 mid-low rectal adenocarcinoma: A 10-year retrospective analysis of patients with a minimum 5-year follow-up.Journal of robotic surgery · 2026Article
- Metabolomic Profiling of Erector Spinae Plane Block for Breast Cancer Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Prognostic impact of postoperative fixed-point inflammation in patients with gastric cancer after curative gastrectomy: A validation cohort study.Annals of gastroenterological surgery · 2025Article
- Surgical stress response and long-term survival in robot-assisted versus laparoscopic surgery for colon cancer: a propensity matched nationwide cohort study.Techniques in coloproctology · 2025Article
- Pan-immune-inflammation in colon cancer: A prognostic biomarker and the role of tumor location in personalized care.World journal of gastrointestinal surgery · 2025Article
- Physical exercise as a potential adjuvant therapy: effects on inflammation and nutrition in colorectal cancer patients-a systematic review and meta-analysis.Frontiers in nutrition · 2025Review
- Combining Preoperative and Postoperative Prognostic Nutritional Index as an Improved Prognostic Factor for Overall Survival in Patients with Colorectal Cancer.Journal of inflammation research · 2025Article
- C-reactive protein and digestive pathologies: A narrative review for daily clinical use.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Low muscle mass-to-fat ratio is an independent factor that predicts worse overall survival and complications in patients with colon cancer: a retrospective single-center cohort study.Annals of surgical treatment and research · 2024Article
- Impact of severe postoperative complications on the prognosis of older patients with colorectal cancer: a two-center retrospective study.BMC gastroenterology · 2024Article
- Article
- The value of C-reactive protein, leucocytes and vital signs in detecting major complications after oncological colorectal surgery.Langenbeck's archives of surgery · 2024Article
- Robotic natural orifice specimen extraction surgery I-type F methodWorld journal of gastrointestinal surgery · 2023Article
- Obesity paradox as a new insight from postoperative complications in gastric cancer.Scientific reports · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemic inflammatory response is strongly linked to among cancer development, progression and poor prognosis. The aim of this study was to clarify the impact of postoperative serum C-reactive protein (CRP) levels on the prognoses of patients with colorectal cancer (CRC).
methodsA total of 467 patients with stage I-III CRC who underwent curative surgery were retrospectively analyzed. To precisely evaluate the effect of postoperative inflammatory status on prognosis in CRC patients, we excluded patients with postoperative complication or elevated preoperative CRP level (CRP > 1.0 mg/dL). Patients were divided into two groups based on their highest post-resection CRP levels (max CRP): the low CRP group (LCG; < 9.0 mg/dL, n = 385) and high CRP group (HCG; ≥ 9.0 mg/dL, n = 82). Furthermore, the effect of inflammation on malignant potential of CRC cells was evaluated using in vitro peritoneal dissemination model.
resultsHCG patients showed significantly worse recurrence-free survival (RFS) than LCG patients (p = 0.012). Multivariate analysis revealed that a higher max CRP was an independent prognostic factor for RFS (HR: 2.07, 95% CI 1.04-3.96, p = 0.038). Concerning the risk factors for high max CRP level, multivariate analysis revealed that older age (p < 0.001), male sex (p < 0.001), higher BMI (p = 0.005), right-sided colorectal cancer (p = 0.008), and longer operative time (p = 0.007) were independent risk factors. A higher max CRP was also significantly associated with peritoneal recurrence (p < 0.001). Additionally, recombinant cytokines enhanced the adhesive ability of CRC cells to mesothelial cell in vitro (p < 0.05).
conclusionsPostoperative inflammation may be a possible mechanism portending the poor prognosis of CRC patients.
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