ArticleMikrochimica acta2019
Modification of a nitrocellulose membrane with cellulose nanofibers for enhanced sensitivity of lateral flow assays: application to the determination of Staphylococcus aureus.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Transport-Reaction-Signal Coupling in Lateral Flow Assays for Next-Generation Point-of-Care Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Revolutionizing Healthcare With Paper-Based Nucleic Acid Testing.Exploration (Beijing, China) · 2026Review
- Exploring carbohydrate binding module fusions and Fab fragments in a cellulose-based lateral flow immunoassay for detection of cystatin C.Scientific reports · 2022Article
- Dual-stimuli-responsive porous polymer enzyme reactor for tuning enzymolysis efficiency.Mikrochimica acta · 2021Article
- Modification of a nitrocellulose membrane with nanofibers for sensitivity enhancement in lateral flow test strips.RSC advances · 2021Article
- Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review.Biomedicines · 2021Review
- A Cellulose Paper-Based Fluorescent Lateral Flow Immunoassay for the Quantitative Detection of Cardiac Troponin I.Biosensors · 2021Article
- Improving the sensitivity of cellulose fiber-based lateral flow assay by incorporating a water-dissolvable polyvinyl alcohol dam.Cellulose (London, England) · 2021Article
- Electrospun nitrocellulose membrane for immunochromatographic test strip with high sensitivity.Mikrochimica acta · 2020Article
- Recent advances in cellulose-based membranes for their sensing applications.Cellulose (London, England) · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateral flow assays, as a low-cost, simple, portable and disposable product of vitro diagnostic, are being widely used for point-of-care testing. However, the poor sensitivity of LFAs is the main challenge for commercialization. In order to enhance the sensitivity of LFAs, cellulose nanofibers (CNFs) have been integrated into LFAs to enhance the sensitivity of protein LFAs. A simple method is also presented to modify the properties of paper substrate by incorporating CNFs into a nitrocellulose membrane to enhance the sensitivity of nucleic acid LFAs. This method changes the pore size, porosity, surface groups and surface area of paper substrate and then increases the adsorption ability of biomolecules on paper substrate. The results indicate that the sensitivity of nucleic acid LFAs in Staphylococcus aureus testing achieves a 20-fold enhancement. Hence, we anticipate that this simple method has the potential for other paper-based devices to improve the performance. Graphical abstractA simple method is used to modify the properties of paper substrate by incorporating cellulose nanofibers (CNFs) into nitrocellulose (NC) membrane to enhance the sensitivity of nucleic acid LFAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.