ReviewJournal of neural transmission (Vienna, Austria : 1996)2020
Nocebo and the contribution of psychosocial factors to the generation of pain.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 58 citations in OpenAlex.
- The "Are You OK?" Paradox: A Scoping Review of Nocebo and Negative Suggestion in Healthcare Communication.Dentistry journal · 2026Review
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- Placebo: a brief updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- Unraveling Negative Expectations and Nocebo-Related Effects in Musculoskeletal Pain.Frontiers in psychology · 2022Article
- Action-Shapers and Their Neuro-Immunological Foundations.Frontiers in psychology · 2022Article
- Editorial: Harnessing placebo mechanisms.Frontiers in psychiatry · 2022Article
- Placebo From an Enactive Perspective.Frontiers in psychology · 2021Article
- The Unintended Consequences of Adverse Event Information on Medicines' Risks and Label Content.Pharmaceutical medicine · 2020Article
- Advances in the understanding and treatment of pain and headache.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biopsychosocial model claims that illness is generated by biological, psychological, and social factors. The nocebo response, particularly nocebo hyperalgesia, is an excellent model and approach to understand these effects and their psychophysiological underpinnings, as nocebos are made of negative psychological and social factors, such as negative expectations and social interactions. There is today experimental evidence that nocebos can create symptoms and illness from nothing, in particular pain, whereby a combination of biological, psychological and social factors interact with each other in the generation of the global painful experience. Several biochemical pathways have been identified, e.g. cholecystokinin and cyclooxygenase, and the activation of these mechanisms has been specifically investigated in the field of pain, analgesia and hyperalgesia. The study of placebo and nocebo oxygen at high-altitude has been crucial to unravel these mechanisms, as reduction of oxygen pressure (hypoxia) leads to headache pain. Indeed, the investigation of oxygen-related conditions, such as hypoxia, represents today an excellent approach to understand how nocebos can contribute to generate illness and pain. In this review we discuss old and new findings that help us better understand the interplay between biology and psychology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.