Evidence map›Paper›PMID 31758217›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2019

Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death.

Saurav Bhowmick, Veera D'Mello, Danielle Caruso, P M Abdul-Muneer

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Ironing out mechanisms of ferroptotic death to tailor new stroke therapies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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  7. Review
  8. Article
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Impact of NQO1 dysregulation in CNS disorders.Journal of translational medicine · 2024
    Review
  18. Fisetin exerts neuroprotective effectsFrontiers in pharmacology · 2024
    Article
  19. Potential Neuroprotective Role of Neurotrophin in Traumatic Brain Injury.CNS & neurological disorders drug targets · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Saurav BhowmickLaboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK Medical Center, 65 James St, Edison, NJ, 08820, USA.
Veera D'MelloLaboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK Medical Center, 65 James St, Edison, NJ, 08820, USA.
Danielle CarusoLaboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK Medical Center, 65 James St, Edison, NJ, 08820, USA.
P M Abdul-MuneerLaboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian Health JFK Medical Center, 65 James St, Edison, NJ, 08820, USA. Mohammed.Muneer@hackensackmeridian.org.ORCID 0000-0001-8231-4385
Hackensack Meridian Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies from our group and others have demonstrated that oxidative stress, Ca

Indexed as

ApoptosisOxidative StressAnimalsAntioxidantsBrainBrain Injuries, TraumaticDown-RegulationInflammationMaleMatrix Metalloproteinase 3Matrix Metalloproteinase 9MiceMice, Inbred C57BLMice, TransgenicNADPH Oxidase 1NF-E2-Related Factor 2AntioxidantsMatrix Metalloproteinase 3Matrix Metalloproteinase 9Mmp3 protein, mouseMmp9 protein, mouseNADPH Oxidase 1NF-E2-Related Factor 2NF-kappa BNitric Oxide SynthaseNOX1 protein, mouseTransforming Growth Factor beta1Antioxidant genesNeurodegenerationNeuroinflammationNrf2 signalingOxidative stressTraumatic brain injury

Identifiers

PMID31758217
OpenAlexW2989800764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.