ArticleMolecular psychiatry2020
Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Metabolomics in Depression: What We Learn from Preclinical and Clinical Evidences.Molecular neurobiology · 2025Pooled it
- Exploring serum biomarkers in paediatric psychiatry: the impact of NfL and GFAP.Translational psychiatry · 2026Article
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Psychological medicine · 2026Article
- Graph theory reveals functional connectome disruptions in adolescent major depressive disorder with childhood trauma.Communications medicine · 2026Article
- Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neurobiological mechanisms of electroconvulsive therapy in major depressive disorder: structure-function coupling with gene expression and molecular mechanism.Translational psychiatry · 2026Article
- Weight matters: Higher BMI is associated with changes in the brain connectome in health and depression.Neuroscience applied · 2026Article
- Cortical morphometric inverse divergence alterations in first-episode, treatment-naïve COVID-19 secondary depression correlate with transcriptional signatures.BMC psychiatry · 2025Article
- Brain structural correlates of an impending initial major depressive episode.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Persons at risk for psychosis overestimate social functioning compared to persons with major depressive disorder and community controls.Journal of psychiatric research · 2025Article
- White matter functional connectome gradient dysfunction in major depressive disorder.Psychoradiology · 2025Article
- A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression.Molecular psychiatry · 2024Article
- Transcriptional expression patterns of the cortical morphometric similarity network in progressive supranuclear palsy.CNS neuroscience & therapeutics · 2024Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- The significance of structural rich club hubs for the processing of hierarchical stimuli.Human brain mapping · 2024Article
- Innovative Neuroimaging Biomarker Distinction of Major Depressive Disorder and Bipolar Disorder through Structural Connectome Analysis and Machine Learning Models.Diagnostics (Basel, Switzerland) · 2024Article
- Tissue-Specific Oxysterols as Predictors of Antidepressant (Escitalopram) Treatment Response in Patients With Major Depressive Disorder.Biological psychiatry global open science · 2023Article
- Familial risk for major depression: differential white matter alterations in healthy and depressed participants.Psychological medicine · 2023Article
- Aberrant Resting-State Functional Connectivity in MDD and the Antidepressant Treatment Effect-A 6-Month Follow-Up Study.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
28 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is associated to affected brain wiring. Little is known whether these changes are stable over time and hence might represent a biological predisposition, or whether these are state markers of current disease severity and recovery after a depressive episode. Human white matter network ("connectome") analysis via network science is a suitable tool to investigate the association between affected brain connectivity and MDD. This study examines structural connectome topology in 464 MDD patients (mean age: 36.6 years) and 432 healthy controls (35.6 years). MDD patients were stratified categorially by current disease status (acute vs. partial remission vs. full remission) based on DSM-IV criteria. Current symptom severity was assessed continuously via the Hamilton Depression Rating Scale (HAMD). Connectome matrices were created via a combination of T1-weighted magnetic resonance imaging (MRI) and tractography methods based on diffusion-weighted imaging. Global tract-based metrics were not found to show significant differences between disease status groups, suggesting conserved global brain connectivity in MDD. In contrast, reduced global fractional anisotropy (FA) was observed specifically in acute depressed patients compared to fully remitted patients and healthy controls. Within the MDD patients, FA in a subnetwork including frontal, temporal, insular, and parietal nodes was negatively associated with HAMD, an effect remaining when correcting for lifetime disease severity. Therefore, our findings provide new evidence of MDD to be associated with structural, yet dynamic, state-dependent connectome alterations, which covary with current disease severity and remission status after a depressive episode.
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