ArticleScientific reports2019
Diagnostic Test Efficacy of Meibomian Gland Morphology and Function.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Randomized, double-masked, sham-controlled trial of efficacy and safety of quantum molecular resonance for treating meibomian gland dysfunction.Eye (London, England) · 2025Trial
- Comparison of Meibomian Gland Loss Between Pediatric Patients with Blepharo-Keratoconjunctivitis and Age-Matched Controls Using Non-Contact Meibography.Journal of clinical medicine · 2026Article
- Eyelid and tear-film factors associated with contact lens discomfort symptom burden among wearers attending after-care in Kisumu County, Kenya: a clinic-based cross-sectional study.BMC ophthalmology · 2026Article
- Diurnal Variation of Tear and Meibum Lipids in Healthy Subjects.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Systematic Review and Meta-Analysis: Prevalence of Meibomian Gland Dysfunction Among Adults Aged 40 Years and Older.Journal of clinical medicine · 2026Review
- A modular and adaptable approach for automated morphological feature extraction in meibography images.Scientific reports · 2025Article
- Quantitative evaluation of meibomian gland dysfunction via deep learning-based infrared image segmentation.Frontiers in artificial intelligence · 2025Article
- The Morphologic Characteristics of Meibomian Glands in Allergic Conjunctivitis-Related Dry Eye in Children.Journal of asthma and allergy · 2025Article
- Combined meibomian gland massage and acupuncture enhances tear film and ocular surface health in meibomian gland dysfunction.American journal of translational research · 2025Article
- Efficacy and Safety of Useul for Dry Eye Disease: Protocol for a Randomized, Double-Blind, Placebo-Controlled, Parallel, Phase 2 Clinical Trial.Healthcare (Basel, Switzerland) · 2024Article
- Meibomian Gland Shortening Is Associated With Altered Meibum Composition.Investigative ophthalmology & visual science · 2024Article
- Factors affecting long-term changes of meibomian gland in MGD patients.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Unsupervised Learning Based on Meibography Enables Subtyping of Dry Eye Disease and Reveals Ocular Surface Features.Investigative ophthalmology & visual science · 2023Article
- Meibomian gland morphological changes in ocular herpes zoster patients based on AI analysis.Frontiers in cell and developmental biology · 2022Article
- 2D Short-Time Fourier Transform for local morphological analysis of meibomian gland images.PloS one · 2022Article
- The Efficacy of Clinical Tests to Diagnose Evaporative Dry Eye Disease Related to Meibomian Gland Dysfunction.Journal of ophthalmology · 2022Article
- Quantitative analysis of morphological and functional features in Meibography for Meibomian Gland Dysfunction: Diagnosis and Grading.EClinicalMedicine · 2021Article
- Proposed Algorithm for Management of Meibomian Gland Dysfunction Based on Noninvasive Meibography.Journal of clinical medicine · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD severity. This retrospective, cross-sectional study included 100 MGD patients and 20 controls. The patients were classified into dry eye severity level (DESL) 1-4 based on symptoms and clinical parameters including tear-film breakup time, ocular staining and Schirmer I. The gland loss, length, thickness, density and distortion were analyzed. We compared the morphology between patients and controls; examined their correlations to meibum expressibility, quality, and DESL. Relative to controls, the gland thickness, density and distortion were elevated in patients (p < 0.001 for all tests). The area under the receiver operating characteristic curve was 0.98 (95% confidence interval [CI], 0.96-1.0) for gland loss, and 0.96 (CI 0.91-1.0) for gland distortion, with a cutoff value of six distorted glands yielding a sensitivity of 93% and specificity of 97% for MGD diagnosis. The gland distortion was negatively correlated to the meibum expressibility (r = -0.53; p < 0.001) and DESL (r = -0.22, p = 0.018). In conclusion, evaluation of meibomian gland loss and distortion are valuable complementary clinical parameters to assess MGD status.
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