Evidence map›Paper›PMID 31758074›Full record

ArticleScientific reports2019

Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling.

Clarissa S Craft, Hero Robles, Madelyn R Lorenz, Eric D Hilker, Kristann L Magee, Thomas L Andersen, William P Cawthorn, Ormond A MacDougald, Charles A Harris, Erica L Scheller

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. No UCP1 in the kidney.Molecular metabolism · 2025
    Article
  6. Review
  7. Development and expansion of intramuscular adipose tissue is not dependent on UCP-1-lineage cells in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  8. Article
  9. Review
  10. The benefits of adipocyte metabolism in bone health and regeneration.Frontiers in cell and developmental biology · 2023
    Review
  11. Sympathetic nerve-adipocyte interactions in response to acute stress.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Marrow adipogenic lineage precursor: A new cellular component of marrow adipose tissue.Best practice & research. Clinical endocrinology & metabolism · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Clarissa S CraftDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Hero RoblesDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Madelyn R LorenzDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Eric D HilkerDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Kristann L MageeDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Thomas L AndersenDepartment of Pathology, Odense University Hospital - Department of Clinical Research & Department Molecular Medicine, University of Southern Denmark, Odense, Denmark.
William P CawthornUniversity/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.
Ormond A MacDougaldDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Charles A HarrisDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Erica L SchellerDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA. scheller@wustl.edu.
Washington University in St. Louis · USOdense University Hospital · DKUniversity of Edinburgh · GBUniversity of Michigan–Ann Arbor · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI DEBORAH J VEIS · 2019 to 2026
$6.8M
GLUCOCORTICOID RECEPTOR POST-TRANSLATIONAL MODIFICATIONS IN INSULIN RESISTANCER01DK106083 · NIDDK · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2016 to 2020
$1.7M
Neural regulation of skeletal biology and periodontal disease progression in typeR00DE024178 · NIDCR · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2016 to 2018
$735k
EXTRACELLULAR MATRIX DETERMINANTS OF NERVE EXTENSION IN THE DENTAL CRANIOFACIAL SKELETONR56DE027924 · NIDCR · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2018 to 2018
$272k
Neural regulation of skeletal biology and periodontal disease progression in typeK99DE024178 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHELLER, ERICA LYNN · 2014 to 2015
$203k
Medical Research Council MR/M021394/1NIAMS NIH HHS P30 AR074992NIDCR NIH HHS K99 DE024178NIDCR NIH HHS R00 DE024178NIDCR NIH HHS R56 DE027924NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK106083NIDDK NIH HHS R24 DK092759NIH HHS R24-DK092759NIH HHS R56-DE027924
6 · The paper itself

Abstract

Adipocytes within the skeleton are collectively termed bone marrow adipose tissue (BMAT). BMAT contributes to peripheral and local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and brown adipogenesis, remains unclear. To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1

Indexed as

Gene ExpressionAdipocytesAdipose TissueAdrenergic AgentsAnimalsBone MarrowCell LineageFemaleFluorescent Antibody TechniqueGene Expression RegulationMaleMiceSkeletonUncoupling Protein 1Adrenergic AgentsUCP1 protein, humanUncoupling Protein 1

Identifiers

PMID31758074
PMCPMC6874537
OpenAlexW2990946033

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.