ArticleScientific reports2019
Longitudinal study of the bacterial and fungal microbiota in the human sinuses reveals seasonal and annual changes in diversity.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of Respiratory Microbiomes in Influenza Versus Other Respiratory Infections: Systematic Review and Analysis.International journal of molecular sciences · 2025Pooled it
- The Effect of Amoxicillin with Clavulanate on the Microbiota of Tonsillar Tissue in Disease: a Randomized Control Trial.Microbiology spectrum · 2022Trial
- Bacterial culture and antibiotic resistance pattern in chronic rhinosinusitis among patients who underwent sinus surgery.BMC infectious diseases · 2026Article
- Staphylococci in high resolution: Capturing diversity within the human nasal microbiota.Cell reports · 2025Article
- Microbial Communities and their Functional Role Associated with the Localised Outbreak of Coral Growth Anomalies in Eastern Arabian Sea.Indian journal of microbiology · 2025Article
- Nasal Rinsing with Probiotics-Microbiome Evaluation in Patients with Inflammatory Diseases of the Nasal Mucosa.Journal of clinical medicine · 2025Article
- Early-Life Host-Microbial Interactions and Asthma Development: A Lifelong Impact?Immunological reviews · 2025Review
- Computational and in vitro evaluation of probiotic treatments for nasalProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being.Frontiers in allergy · 2025Review
- Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome.Genome biology · 2024Article
- Elexacaftor-tezacaftor-ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis.International forum of allergy & rhinology · 2024Article
- Gut Fungal Communities Are Influenced by Seasonality in Captive Baikal Teal (Animals : an open access journal from MDPI · 2023Article
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- Upper respiratory tract microbiota dynamics following COVID-19 in adults.Microbial genomics · 2023Article
- Prolonged mask wearing changed nasal microbial characterization of young adults during the COVID-19 pandemic in Shanghai, China.Frontiers in immunology · 2023Article
- The bovine nasal fungal community and associations with bovine respiratory disease.Frontiers in veterinary science · 2023Article
- The Interplay between Gut Microbiota and Parkinson's Disease: Implications on Diagnosis and Treatment.International journal of molecular sciences · 2022Review
- Characterization of Bacterial Differences Induced by Cleft-Palate-Related Spatial Heterogeneity.Pathogens (Basel, Switzerland) · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a pressing need for longitudinal studies which examine the stability of the sinonasal microbiota. In this study, we investigated bacterial and fungal community composition of the sinuses of four healthy individuals every month for one year, then once every three months for an additional year to capture seasonal variation. Sequencing of bacterial 16S rRNA genes and fungal ITS2 revealed communities that were mainly dominated by members of Actinobacteria and Basidiomycota, respectively. We observed overall shifts in both bacterial and fungal community diversity that were attributable to a combination of individual, seasonal and annual changes. The results suggest that each of the subjects possessed a strong bacterial sinonasal signature, but that fungal communities were less subject specific. Differences in fungal and bacterial diversity between subjects, and which OTUs may be correlated with seasonal differences, were investigated. A small core community that persisted throughout the two year sampling period was identified: Corynebacterium, Propionibacterium and Staphylococcus, and one type of fungus, Malassezia restricta. It is likely that bacterial and fungal airway microbiomes are dynamic and experience natural shifts in diversity with time. The underlying reasons for these shifts appear to be a combination of changes in environmental climate and host factors.
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