ArticleNature communications2019
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Inhibiting menin attenuates high-fat diet-induced weight gain by limiting intestinal lipid absorption in mice.The Journal of clinical investigation · 2026Article
- The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026Review
- A Novel Epigenetic Mechanism of Intestinal NHE3 Gene Regulation by Histone Acetylation.International journal of molecular sciences · 2026Article
- Cholecystectomy inhibits fasting hepatic fatty acid oxidation in mice.Communications biology · 2026Article
- A small molecule PTER-selective inhibitor reduces food intake and body weight.bioRxiv : the preprint server for biology · 2026Article
- HDAC3-driven immunometabolic reprogramming in type 2 diabetes and its complications: from enzymatic deacetylation to non-enzymatic scaffolding.Frontiers in immunology · 2026Review
- Interplay between gut microbiota and intestinal lipid metabolism:mechanisms and implications.Journal of Zhejiang University. Science. B · 2025Review
- Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome.Current obesity reports · 2025Review
- Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.Endocrinology · 2024Article
- Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity.Immunity · 2024Article
- Inflammaging and fatty acid oxidation in monocytes and macrophages.Immunometabolism (Cobham, Surrey) · 2024Review
- Anti-Obesity Potential through Regulation of Carbohydrate Uptake and Gene Expression in Intestinal Epithelial Cells by the ProbioticJournal of microbiology and biotechnology · 2023Article
- The role of HDAC3 and its inhibitors in regulation of oxidative stress and chronic diseases.Cell death discovery · 2023Review
- Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms.Gastroenterology · 2022Article
- Flaxseed Polysaccharide Alters Colonic Gene Expression of Lipid Metabolism and Energy Metabolism in Obese Rats.Foods (Basel, Switzerland) · 2022Article
- Modulation of cellular processes by histone and non-histone protein acetylation.Nature reviews. Molecular cell biology · 2022Review
- The Protective Role of Bmal1-Regulated Autophagy Mediated by HDAC3/SIRT1 Pathway in Myocardial Ischemia/Reperfusion Injury of Diabetic Rats.Cardiovascular drugs and therapy · 2022Article
- Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.Amino acids · 2022Article
- The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity.Frontiers in nutrition · 2022Review
- The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-ResistantFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
24 authors at 6 institutions in 2 countries.
Mercedes Dávalos-SalasOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-0692-5904
Magdalene K MontgomeryDepartment of Physiology, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Camilla M ReehorstOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-8039-3582
Rebecca NightingaleOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Irvin NgOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-1357-4666
Holly AndertonOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-3913-9686
Sheren Al-ObaidiOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Analia LesmanaOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Cameron M ScottOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Paul IoannidisOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-1003-7478
Hina KalraLa Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Shivakumar KeerthikumarLa Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.
Lars TögelOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-0612-6440
Angela RigopoulosOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Sylvia J GongOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
David S WilliamsOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Prusoth YoganantharajaDepartment of Medicine, Deakin University, Geelong, Victoria, Australia.
Kim Bell-AndersonFaculty of Science, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-7761-3441
Suresh MathivananLa Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7290-5795
Yann GibertDepartment of Medicine, Deakin University, Geelong, Victoria, Australia.
Scott HiebertVanderbilt University, Nashville, TN, USA.
Andrew M ScottOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia.
Matthew J WattDepartment of Physiology, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia. matt.watt@unimelb.edu.
John M MariadasonOlivia Newton John Cancer Research Institute, Melbourne, Victoria, Australia. john.mariadason@onjcri.org.au.ORCID http://orcid.org/0000-0001-9123-7684
La Trobe University · AUOlivia Newton-John Cancer Wellness & Research Centre · AUThe University of Melbourne · AUDeakin University · AUThe University of Sydney · AUVanderbilt University · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MRole of AML1-ETO in Acute LeukemiaR01CA064140 · NCI · VANDERBILT UNIVERSITY · PI HIEBERT, SCOTT W · 1994 to 2018
$5.7MHdac3 as a therapeutic target in BCL6-dependent lymphomaR01CA164605 · NCI · VANDERBILT UNIVERSITY · PI HIEBERT, SCOTT W · 2012 to 2022
$3.9MRegulation of transcription and tumor suppression by MTG family membersR01CA178030 · NCI · VANDERBILT UNIVERSITY · PI HIEBERT, SCOTT W · 2014 to 2018
$1.8MNCI NIH HHS R01 CA064140NCI NIH HHS R01 CA164605NCI NIH HHS R01 CA178030NIDDK NIH HHS P30 DK058404
Abstract
Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is unknown. Here we demonstrate that intestine-specific deletion of Hdac3 (Hdac3
Indexed as
AnimalsCalorimetryDiet, High-FatEnterocytesFatty AcidsGene DeletionGene Expression RegulationHistone Deacetylase 3Histone DeacetylasesIntestinal MucosaLipid MetabolismLipidomicsLipid PeroxidationMiceMitochondriaObesityFatty AcidsHistone Deacetylase 3Histone DeacetylasesPeroxisome Proliferator-Activated ReceptorsTriglycerides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.