ArticleGut2020
microRNA overexpression in slow transit constipation leads to reduced Na
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Article in Gut, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
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Who cites it
30 citing papers in PubMed, 31 citations in OpenAlex.
- Animal Models of Slow-Transit Constipation: Current Progress, Limitations, and Future Perspectives.Digestive diseases and sciences · 2026Review
- Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Maladaptive Piezo1 Mechanotransduction Drives Smooth Muscle Aging in the Gut.bioRxiv : the preprint server for biology · 2026Article
- Diagnosis and treatment of slow-transit constipation.BMC gastroenterology · 2026Review
- Article
- Pathophysiological mechanisms, diagnostic innovations, and multimodal therapeutic strategies for slow transit constipation.BMC gastroenterology · 2025Review
- Feature tracking-based motility analysis of excised intestinal tissue using video recordings.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- MicroRNA regulation of enteric nervous system development and disease.Trends in neurosciences · 2025Review
- Thiamine, gastrointestinal beriberi and acetylcholine signaling.Frontiers in nutrition · 2025Review
- Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway:Frontiers in pharmacology · 2025Article
- Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway.Frontiers in pharmacology · 2025Review
- Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.World journal of gastroenterology · 2024Article
- Conotoxins Targeting Voltage-Gated Sodium Ion Channels.Pharmacological reviews · 2024Review
- miR-10b-5p rescues leaky gut linked with gastrointestinal dysmotility and diabetes.United European gastroenterology journal · 2023Article
- Altered gut microbial profile is associated with differentially expressed fecal microRNAs in patients with functional constipation.Frontiers in microbiology · 2023Article
- Tracking Gut Motility in Organ and Cultures.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Analysis of Key Genes for Slow Transit Constipation Based on RNA Sequencing.International journal of general medicine · 2022Article
- Electroacupuncture Improves Intestinal Motility through Exosomal miR-34c-5p Targeting SCF/c-Kit Signaling Pathway in Slow Transit Constipation Model Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation.Frontiers in cellular and infection microbiology · 2022Article
- Efficacy and MicroRNA-Gut Microbiota Regulatory Mechanisms of Acupuncture for Severe Chronic Constipation: Study Protocol for a Randomized Controlled Trial.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 2 countries.
Amelia MazzoneEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Peter R StregeEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Simon J GibbonsEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5311-5993
Constanza AlcainoEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Vikram JoshiEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Andrew J HaakDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Daniel J TschumperlinDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Cheryl E BernardEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Robert R CimaDepartment of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA.
David W LarsonDepartment of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Heidi K ChuaDepartment of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Rondell P GrahamDepartment of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Mona El RefaeyDepartments of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Peter J MohlerDepartments of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Yujiro HayashiEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Tamas OrdogEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3940-7284
Stefan CalderAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Peng DuAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-6913-7545
Gianrico FarrugiaEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA farrugia.gianrico@mayo.edu beyder.arthur@mayo.edu.ORCID 0000-0003-3473-5235
Arthur BeyderEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA farrugia.gianrico@mayo.edu beyder.arthur@mayo.edu.ORCID 0000-0002-9225-4854
Mayo Clinic · USThe Ohio State University Wexner Medical Center · USUniversity of Auckland · NZ
Funding
PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI MARK A. MC NIVEN · 2009 to 2026
$22.2MMECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLSR01DK052766 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR, FARRUGIA, GIANRICO · 1997 to 2025
$8.3MMechanotransduction in gastrointestinal physiologyR01DK123549 · NIDDK · MAYO CLINIC ROCHESTER · PI Arthur Beyder · 2019 to 2026
$3.7MDoes the gut have a sense of touch?DP2AT010875 · NCCIH · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2019 to 2019
$2.4MMechanisms of mechanotransduction in the enterochromaffin cellsK08DK106456 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2015 to 2019
$813kDefining new pathways for cardiac automaticityK99HL146969 · NHLBI · OHIO STATE UNIVERSITY · PI EL REFAEY, MONA · 2019 to 2020
$194kEnterochromaffin cell mechanotransduction and mechanosensitive serotonin release depend on calcium signaling downstream of Piezo2 activationR03DK119683 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2019 to 2020
$159kNCCIH NIH HHS DP2 AT010875NHLBI NIH HHS K99 HL146969NIDDK NIH HHS K08 DK106456NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK052766NIDDK NIH HHS R01 DK123549NIDDK NIH HHS R03 DK119683
Abstract
objectiveThis study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC).
designAll human tissue samples were from the
resultsThe expression of 13 miRNAs was increased in STC samples. Of those miRNAs, four were predicted to target
conclusionsA small group of miRNAs is upregulated in STC, and many of these miRNAs target the SCN5A-encoded Na
Indexed as
Gene Expression RegulationAdultAgedBiopsy, NeedleCase-Control StudiesColonConstipationFemaleGastrointestinal MotilityHumansImmunohistochemistryMicroRNAsMicrotubule-Associated ProteinsMiddle AgedMuscle ContractionMuscle, SmoothMicroRNAsMicrotubule-Associated ProteinsNAV1 protein, humanRNA, Messengerconstipationgeneticsintestinal ion transportintestinal motilitymotility disorders
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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.