ArticleNeuron2020
Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors.Neuron · 2026Article
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- Spatiotemporally dynamic noradrenergic regulation of cortical networks.bioRxiv : the preprint server for biology · 2026Article
- Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.Current biology : CB · 2026Article
- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
- Visual experience drives functional reorganization of cortical GABAergic circuits.bioRxiv : the preprint server for biology · 2026Article
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- Delayed integration of somatostatin interneurons into visual circuits.Nature communications · 2025Article
- Atypical cortical feedback underlies failure to process contextual information in the superior colliculus of Scn2aNature communications · 2025Article
- Primary auditory cortex is necessary for the acquisition and expression of categorical behavior.Current biology : CB · 2025Article
- Learning, prediction accuracy, and neural plasticity in sensory cortex.Current opinion in neurobiology · 2025Review
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- Fast implicit and slow explicit learning of temporal context.Scientific reports · 2025Article
- Higher-order thalamic input to cortex selectively conveys state information.Cell reports · 2025Article
- Article
- Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex.Nature communications · 2024Article
- Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Analyzing top-down visual attention in the context of gamma oscillations: a layer- dependent network-of- networks approach.Frontiers in computational neuroscience · 2024Article
- Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior.Nature neuroscience · 2024Article
- A direction-selective cortico-brainstem pathway adaptively modulates innate behaviors.Nature communications · 2023Article
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Abstract
Neocortical sensory areas are thought to act as distribution hubs, transmitting information about the external environment to downstream areas. Within primary visual cortex, various populations of pyramidal neurons (PNs) send axonal projections to distinct targets, suggesting multiple cellular networks may be independently engaged during behavior. We investigated whether PN subpopulations differentially support visual detection by training mice on a novel eyeblink conditioning task. Applying 2-photon calcium imaging and optogenetic manipulation of anatomically defined PNs, we show that layer 5 corticopontine neurons strongly encode sensory and motor task information and are selectively necessary for performance. Our findings support a model in which target-specific cortical subnetworks form the basis for adaptive behavior by directing relevant information to distinct brain areas. Overall, this work highlights the potential for neurons to form physically interspersed but functionally segregated networks capable of parallel, independent control of perception and behavior.
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