Trial reportDrug and alcohol dependence2020
Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.
Trial report in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Effect of amphetamines on blood pressure.The Cochrane database of systematic reviews · 2025Pooled it
- Connectome-based encoding of subjective drug responses to acute oral methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Lack of effect of methamphetamine on reward-related brain activity in healthy adults.Psychopharmacology · 2024Trial
- Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults.Psychopharmacology · 2023Trial
- Striatal activation to monetary reward is associated with alcohol reward sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward.Journal of psychopharmacology (Oxford, England) · 2024Article
- Amphetamine-induced dopamine release in rat: Whole-brain spatiotemporal analysis with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders.Genes · 2023Review
- Anger, agency, risk and action: a neurobehavioral model with proof-of-concept in healthy young adults.Frontiers in psychology · 2023Article
- Human Primary Olfactory Amygdala Subregions Form Distinct Functional Networks, Suggesting Distinct Olfactory Functions.Frontiers in systems neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDrug addiction and dependence continue as an unresolved source of morbidity and mortality. Two approaches to identifying risk for abuse and addiction are psychopharmacological challenge studies and neuroimaging experiments. The present study combined these two approaches by examining associations between self-reported euphoria or liking after a dose of d-amphetamine and neural-based responses to anticipation of a monetary reward.
methodsHealthy young adults (N = 73) aged 19 and 26, without any history of alcohol/substance dependence completed four laboratory sessions in which they received oral d-amphetamine (20 mg) or placebo, and completed drug effect questionnaires. On a separate session they underwent a functional magnetic resonance imaging scan while they completed a monetary incentive delay task. During the task, we recorded neural signal related to anticipation of winning $5 or $1.50 compared to winning no money (WinMoney-WinZero), in reward related regions.
resultsLiking of amphetamine during the drug sessions was related to differences in activation during the WinMoney-WinZero conditions - in the amygdala (positive), insula (negative) and caudate (negative). In posthoc analyses, liking of amphetamine was also positively correlated with activation of the amygdala during anticipation of large rewards and negatively related to activation of the left insula to both small and large anticipated rewards.
conclusionsThese findings suggest that individual differences in key regions of the reward network are related to rewarding subjective effects of a stimulant drug. To further clarify these relationships, future pharmacofMRI studies could probe the influence of amphetamine at the neural level during reward anticipation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.