ArticleThe Journal of allergy and clinical immunology2020
Atopic eczema and fracture risk in adults: A population-based cohort study.
Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Atopic dermatitis and the risk of osteoporosis and fractures: a meta-analysis of cohort studies.Annals of medicine · 2026Pooled it
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate-to-Severe Atopic Dermatitis.Allergy · 2025Trial
- Ovalbumin-induced asthma leads to bone loss with Piezo channel suppression in mice.Communications biology · 2025Article
- Atopic Dermatitis beyond Eczema: A Review on its Systemic Impact through Pruritus and Associated Comorbidities.Clinical reviews in allergy & immunology · 2025Review
- Causal association of allergic diseases, eosinophils, and osteoporosis: A Mendelian randomization study.The World Allergy Organization journal · 2025Article
- Inflammation and aging-related disease: A transdisciplinary inflammaging framework.GeroScience · 2025Review
- Cohort studies on 71 outcomes among people with atopic eczema in UK primary care data.Nature communications · 2024Article
- Incident Asthma, Asthma Exacerbations, and Asthma-Related Hospitalizations in Patients With Atopic Dermatitis.The journal of allergy and clinical immunology. In practice · 2024Article
- Allergic Phenotypes and Sarcopenia: Evidence from Observational Studies and Mendelian Randomization Analysis.Phenomics (Cham, Switzerland) · 2024Article
- The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review.Skin health and disease · 2023Article
- Risk of Inflammatory Bowel Disease in Patients With Atopic Dermatitis.JAMA dermatology · 2023Article
- Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK.BMC medicine · 2023Article
- Link between obesity and atopic dermatitis: Does obesity predispose to atopic dermatitis, or vice versa?Experimental dermatology · 2023Review
- Anxiety and Depression in People with Eczema or Psoriasis: A Comparison of Associations in UK Biobank and Linked Primary Care Data.Clinical epidemiology · 2023Article
- Atopic dermatitis and risk of major neuropsychiatric disorders in children: A population-based cohort study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
- Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis.Scientific reports · 2022Article
- Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases.International journal of molecular sciences · 2022Review
- Risk of herpesvirus, serious and opportunistic infections in atopic dermatitis: a population-based cohort study.The British journal of dermatology · 2022Article
- Atopic Eczema-Associated Fracture Risk and Oral Corticosteroids: A Population-Based Cohort Study.The journal of allergy and clinical immunology. In practice · 2022Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLimited evidence suggests increased fracture risk in people with atopic eczema. Any link could have substantial effect; atopic eczema is common, and fractures have associated morbidity and mortality.
objectiveWe sought to examine whether atopic eczema is associated with fracture and whether fracture risk varies with eczema severity.
methodsWe performed a matched cohort study set in primary care (Clinical Practice Research Datalink GOLD 1998-2016) and linked hospital admissions data (Hospital Episode Statistics), including adults (≥18 years old) with atopic eczema matched (by age, sex, general practice, and cohort entry date) with up to 5 individuals without eczema. We estimated hazard ratios (HRs) from stratified Cox regression comparing risk of major osteoporotic (hip, pelvis, spine, wrist, and proximal humerus) fractures individually and any fracture in those with and without atopic eczema.
resultsWe identified 526,808 people with atopic eczema and 2,569,030 people without atopic eczema. Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity, with the strongest associations in people with severe eczema (compared with those without) for spinal (HR, 2.09; 99% CI, 1.66-2.65), pelvic (HR, 1.66; 99% CI, 1.26-2.20), and hip (HR, 1.50; 99% CI, 1.30-1.74) fractures. Associations persisted after oral glucocorticoid adjustment.
conclusionsPeople with atopic eczema have increased fracture risk, particularly major osteoporotic fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.