Evidence map›Paper›PMID 31757473›Full record

Trial reportThe Journal of pediatrics2020

Effect of Aspiration and Evaluation of Gastric Residuals on Intestinal Inflammation, Bleeding, and Gastrointestinal Peptide Level.

Leslie A Parker, Michael Weaver, Roberto J Murgas Torrazza, Jonathon Shuster, Nan Li, Charlene Krueger, Josef Neu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01863043 (Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01863043 nacompletednot on this map

Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants

TypeinterventionalSponsorUniversity of FloridaRan2013 to 2019Enrolled146ConditionsInfant, Premature, Nutrition, EnteralArmsNo aspiration of gastric contents, Routine aspiration of gastric contents
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leslie A ParkerCollege of Nursing, University of Florida, Gainesville, FL. Electronic address: Parkela@ufl.edu.
Michael WeaverCollege of Nursing, University of Florida, Gainesville, FL.
Roberto J Murgas TorrazzaSistema Nacional de Investigacion de Panama, Secretaria Nacional de Ciencia Tecnologia e Innovacion, Panama City, Panama.
Jonathon ShusterDepartment of Health Outcomes and Bioinformatics, University of Florida, Gainesville, FL.
Nan LiDepartment of Pediatrics, University of Florida, Gainesville, FL.
Charlene KruegerCollege of Nursing, University of Florida, Gainesville, FL.
Josef NeuDepartment of Pediatrics, University of Florida, Gainesville, FL.

Funding

Preventing Obesity through Intervention during InfancyR01DK088244 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PAUL, IAN M, WILLIAMS, JENNIFER SAVAGE · 2011 to 2022
$7.0M
Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight InfantsR01NR014019 · NINR · UNIVERSITY OF FLORIDA · PI PARKER, LESLIE A · 2013 to 2016
$1.3M
NIDDK NIH HHS R01 DK088244NINR NIH HHS R01 NR014019
6 · The paper itself

Abstract

objectiveTo determine the effect of gastric residual aspiration and evaluation on preterm very low birth weight infants' gastrointestinal function, intestinal inflammation, and gastrointestinal mucosal bleeding. STUDY

designThis single-center, randomized trial compared omission of gastric residuals vs prefeed gastric residuals in 143 infants ≤32 weeks of gestation with a birthweight of ≤1250 g for 6 weeks after birth. Serum levels of gastrin and motilin were collected between 14 and 21 days of life. Stools were collected at 3 and 6 weeks of age and analyzed for calprotectin and S100A12 levels. All stools were tested for occult blood for 6 weeks.

resultsMeans for gastrin (P = .999) and motilin (P = .694) were similar between groups and there were no statistically significant differences in adjusted means for transformed calprotectin (P = .580), and S100A12 (P = .212). Both calprotectin (P = .003) and S100A12 (P = .002) increased from week 3 to week 6. The mean percentage of stools positive for occult blood (P = .888) were similar between the groups.

conclusionsGastrointestinal function, intestinal inflammation, and gastrointestinal mucosal bleeding were similar whether aspiration and evaluation of gastric residuals were eliminated or not, suggesting routinely evaluating gastric residuals before every feeding may be unnecessary. TRIAL REGISTRATION CLINICALTRIALS.GOV:: NCT01863043.

Indexed as

Infant, Very Low Birth WeightEnteral NutritionEnterocolitis, NecrotizingFemaleFollow-Up StudiesGastrointestinal ContentsGastrointestinal HemorrhageHumansIncidenceInfant, NewbornMaleRetrospective StudiesRisk FactorsUnited Statesgastric residualneonatal intensive care unitprematurevery low birth weight

Identifiers

PMID31757473
PMCPMC7012706

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.