Evidence map›Paper›PMID 31757312›Full record

ReviewSurgical oncology clinics of North America2020

Genomics and the History of Precision Oncology.

Deborah B Doroshow, James H Doroshow

Abstract readHistorical ArticleReview
In one paragraph

Review in Surgical oncology clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Nurses' Genomic Knowledge, Attitudes, and Perceived Organizational Support: A Comparative Secondary Analysis of Genetics and Genomics in Nursing Practice Survey Data.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Is Histopathology Deep Learning Artificial Intelligence the Future of Precision Oncology?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Desk of the editor (Addendum Vol.12 Issue 1 E).Indian journal of surgical oncology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Deborah B DoroshowDepartment of Medicine and Cancer Center, Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Place, New York, NY 10029, USA.
James H DoroshowDivision of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Suite 3A44, Building 31, 31 Center Drive, Bethesda, MD 20892, USA. Electronic address: doroshoj@mail.nih.gov.

Funding

Phase 01 Clinical TrialsZIABC011078 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DOROSHOW, JAMES · 2009 to 2025
$9.0M
Phase 01 Clinical TrialsZ01BC011078 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DOROSHOW, JAMES · 2008 to 2008
$96k
Intramural NIH HHS Z01 BC011078Intramural NIH HHS ZIA BC011078
6 · The paper itself

Abstract

Progress toward the implementation of a molecular characterization paradigm in cancer drug development over the past 20 years has markedly enhanced our capability to select patients who are more likely to benefit from cancer therapy. Improvements in genomic and related diagnostic testing platforms have permitted evaluation of the efficacy of treatment assignment based on predefined biologic features of a patient's tumor or germline using master protocols that may include many malignancies and their molecularly characterized subsets. With this approach, a wide range of new targeted and immunologic treatment approaches have been defined for patients who, heretofore, lacked effective therapeutic options.

Indexed as

Antineoplastic AgentsBiomarkers, TumorHistory, 21st CenturyHumansMolecular Targeted TherapyNeoplasmsPharmacogeneticsPrecision MedicineAntineoplastic AgentsBiomarkers, TumorBasket trialBucket trialCancer drug developmentMaster protocolPrecision oncology

Identifiers

PMID31757312
PMCPMC6878897

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.