ArticleInternational journal of molecular sciences2019
CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia.
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Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- Integration of Multi-Omics Data To Understand the Multifaceted Role of RAMP1 across Different Cancer Types.Cell biochemistry and biophysics · 2026Review
- Article
- Diving into the transcriptional landscape of leukemic stem cells in acute myeloid leukemia at single-cell resolution.Journal of cancer research and clinical oncology · 2026Review
- Identification of the key immune and inflammatory related gene CALCRL as diagnostic biomarker in differentiating uterine leiomyosarcoma from leiomyoma.Frontiers in cell and developmental biology · 2026Article
- The Clinical Relevance and Prognostic Significance of Calcitonin Receptor-Like (CALCRL) Gene Expression in AML Patients.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression.Nature communications · 2025Article
- Quantitative proteomics reveals CLR interactome in primary human cells.The Journal of biological chemistry · 2024Article
- Crosstalk Between Peripheral Innervation and Pancreatic Ductal Adenocarcinoma.Neuroscience bulletin · 2023Review
- Peptidergic Systems and Cancer: Focus on Tachykinin and Calcitonin/Calcitonin Gene-Related Peptide Families.Cancers · 2023Review
- Identification of Novel Genes for Cell Fusion during Osteoclast Formation.International journal of molecular sciences · 2022Article
- Article
- Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance.Journal of oncology · 2022Article
- The connection between innervation and metabolic rearrangements in pancreatic cancer through serine.Frontiers in oncology · 2022Review
- CGRP: A New Endogenous Cell Stemness Maintenance Molecule.Oxidative medicine and cellular longevity · 2022Review
- Gene expression changes contribute to stemness and therapy resistance of relapsed acute myeloid leukemia: roles of SOCS2, CALCRL, MTSS1, and KDM6A.Experimental hematology · 2021Review
- Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells.Nature communications · 2021Article
- Prognostic Signatures Based on Ferroptosis- and Immune-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma.Frontiers in oncology · 2021Article
- Comprehensive Analysis of Inflammatory Response-Related Genes, and Prognosis and Immune Infiltration in Patients With Low-Grade Glioma.Frontiers in pharmacology · 2021Article
- Integration of a 4-gene risk score model enhances prognostic accuracy in acute myeloid leukemia.Cell cycle (Georgetown, Tex.)Article
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Authors and funding
16 authors at 7 institutions in 2 countries.
Tobias GluexamDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Alexander M GranditsDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Angela SchlerkaDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Chi Huu NguyenDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Julia EtzlerDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0001-9475-1443
Thomas FinkesDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Michael FuchsDepartment I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Christoph ScheidDepartment I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Gerwin HellerDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0001-8742-5631
Hubert HacklInstitute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria.ORCID 0000-0003-4055-3841
Nathalie HarrerDepartment for Cancer Research, Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, A-1121 Vienna, Austria.
Heinz SillDivision of Hematology, Medical University of Graz, Auenbruggerplatz 38, 8036 Graz, Austria.ORCID 0000-0003-0993-4371
Elisabeth KollerThird Medical Department, Hanusch Hospital, Heinrich Collinstrasse 30, 1140 Vienna, Austria.ORCID 0000-0002-9912-0461
Dagmar StoiberInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090 Vienna, Austria.
Wolfgang SommergruberDepartment of Biotechnology, University of Applied Sciences, Helmut-Qualtinger-Gasse 2, 1030 Vienna, Austria.
Rotraud WieserDivision of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0003-4384-6658
Comprehensive Cancer Center Vienna · ATUniversity of Cologne · DEBoehringer Ingelheim (Austria) · ATHanusch Hospital · ATInnsbruck Medical University · ATKarl Landsteiner University of Health Sciences · ATMedical University of Graz · AT
Funding
Austrian Science Fund P-28013Austrian Science Fund P-28256Austrian Science Fund FWF P 28013Austrian Science Fund FWF P 28256
Abstract
The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. Recently, high
Indexed as
Drug Resistance, NeoplasmAnimalsAntibiotics, AntineoplasticApoptosisCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinCell Line, TumorDaunorubicinDipeptidesFemaleHematopoietic Stem CellsHumansLeukemia, Myeloid, AcuteMaleMiceMice, Inbred C57BLAntibiotics, AntineoplasticCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinCALCRL protein, humanDaunorubicinDipeptidesolcegepantPiperazinesQuinazolinesAMLCALCRLCGRPchemotherapy resistanceleukemic stem cellsolcegepantrelapse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.