Evidence map›Paper›PMID 31756952›Full record

ReviewInternational journal of molecular sciences2019

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment.

Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 1 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.

  1. Pooled it
  2. Vitamin DIn vivo (Athens, Greece)
    Trial
  3. Article
  4. Review
  5. TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  6. [Ethanol promotes oxaliplatin resistance in colorectal cancer by activating the TGF‑β/Smad/P21 signaling axis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. The Role of Tenascin-C in Neuroinflammation and Neuroplasticity.International journal of molecular sciences · 2025
    Review
  19. Article
  20. Review

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yoshiro ItataniDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0001-7356-7065
Kenji KawadaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0003-4336-6937
Yoshiharu SakaiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Kyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways that play key roles for tissue maintenance. In particular, it is important in the context of inflammation and tumorigenesis by modulating cell growth, differentiation, apoptosis, and homeostasis. TGF-β receptor type 2 (

Indexed as

Signal TransductionTumor MicroenvironmentAnimalsColorectal NeoplasmsHumansTransforming Growth Factor betaTransforming Growth Factor betacolorectal cancerSMAD4TGF-β signalingtumor microenvironment

Identifiers

PMID31756952
PMCPMC6929101
OpenAlexW2989842006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.