ArticleHeart rhythm2020
Skin sympathetic nerve activity and ventricular rate control during atrial fibrillation.
Article in Heart rhythm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG).Nature protocols · 2020Trial
- Using subcutaneous nerve stimulation to control atrial fibrillation.Heart rhythm O2 · 2026Article
- Effects of Pulmonary Vein Isolation for Atrial Fibrillation on Skin Sympathetic Nerve Activity in Association with Left Atrial Remodeling.Journal of cardiovascular development and disease · 2025Article
- Predictive value of inflammatory burden index for new-onset atrial fibrillation in STEMI patients.Frontiers in cardiovascular medicine · 2025Article
- Skin sympathetic nerve activity in symptomatic and asymptomatic paroxysmal atrial fibrillation.Heart rhythm · 2024Article
- Renal autonomic dynamics in hypertension: how can we evaluate sympathetic activity for renal denervation?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Development of neuromodulation for atrial fibrillation: a narrative review.Journal of thoracic disease · 2024Review
- Autonomic Modulation of Atrial Fibrillation.JACC. Basic to translational science · 2023Review
- Skin sympathetic nerve activity as a biomarker for outcomes in spontaneous intracerebral hemorrhage.Annals of clinical and translational neurology · 2023Article
- Evaluation of autonomic nervous system activity in intradialytic hypotension using entropy and skin sympathetic nerve activity.Frontiers in neuroscience · 2023Article
- Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes.BMC cancer · 2022Observational
- An Artifact-Resistant Feature SKNAER for Quantifying the Burst of Skin Sympathetic Nerve Activity Signal.Biosensors · 2022Article
- Molecular Insights in Atrial Fibrillation Pathogenesis and Therapeutics: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Temporal Clustering of Skin Sympathetic Nerve Activity Bursts in Acute Myocardial Infarction Patients.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe relationship between the ventricular rate (VR) during atrial fibrillation (AF) and skin sympathetic nerve activity (SKNA) remains unclear.
objectiveThe purpose of this study was to test the hypothesis that SKNA bursts accelerate VR during AF.
methodsWe simultaneously recorded electrocardiogram and SKNA in 8 patients (median age 66.0 years [interquartile range {IQR} 59.0-77.0 years]; 4 men [50%]) with 30 paroxysmal AF episodes (all >10-minute long) and 12 patients (73.0 years [IQR 60.5-80.0 years]; 6 men [50%]) with persistent AF. The average amplitude of SKNA (aSKNA [μV]) during AF was analyzed in 1-minute windows and binned, showing 2 Gaussian distributions. We used the mean + 3SD of the first Gaussian distribution as the threshold that separates burst from baseline (nonburst) SKNA. All 1-minute aSKNA values above the threshold were detected, and the area between aSKNA and baseline of every 1 minute was calculated and added as burst area.
resultsVR was higher during SKNA bursts than during the nonburst period (103 beats/min [IQR 83-113 beats/min] vs 88 beats/min [IQR 76-101 beats/min], respectively; P = .003). In the highest quartile of the burst area during persistent AF, the scatterplot of maximal aSKNA and VR during each SKNA burst shows higher aSKNA and VR. The overall estimate of the correlation between maximal VR and aSKNA during bursts show a positive correlation in the highest quartile of the burst area (0.64; 95% confidence interval 0.54-0.74; P < .0001).
conclusionSKNA bursts are associated with VR acceleration. These SKNA bursts may be new therapeutic targets for rate control during AF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.