Evidence map›Paper›PMID 31756383›Full record

ArticleContemporary clinical trials2020

Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC).

Tonya M Palermo, Caitlin Murray, Homer Aalfs, Maisam Abu-El-Haija, Bradley Barth, Melena D Bellin, Kate Ellery, Douglas S Fishman, Cheryl E Gariepy, Matthew J Giefer and 24 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03707431 (A Randomized Trial of a Web-based Non-pharmacological Pain Intervention for Pediatric Chronic Pancreatitis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03707431 nacompletednot on this map

A Randomized Trial of a Web-based Non-pharmacological Pain Intervention for Pediatric Chronic Pancreatitis

TypeinterventionalSponsorSeattle Children's HospitalRan2019 to 2024Enrolled90ConditionsChronic Pancreatitis, Acute Recurrent PancreatitisArmsWeb-based CBT, Pain Education
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Observational
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 3 countries.

Tonya M PalermoDepartment of Anesthesiology & Pain Medicine, University of Washington School of Medicine, USA; Center for Child Health, Behavior & Development, Seattle Children's Research Institute, USA. Electronic address: tonya.palermo@seattlechildrens.org.
Caitlin MurrayCenter for Child Health, Behavior & Development, Seattle Children's Research Institute, USA.
Homer AalfsCenter for Child Health, Behavior & Development, Seattle Children's Research Institute, USA.
Maisam Abu-El-HaijaCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Bradley BarthUniversity of Texas Southwestern Medical School, Dallas, TX, USA.
Melena D BellinUniversity of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
Kate ElleryChildren's Hospital; of Pittsburgh, Pittsburgh, PA, USA.
Douglas S FishmanSection of Pediatric Gastroenterology, Hepatology and Nutrition Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Cheryl E GariepyNationwide Children's Hospital, Columbus, OH, USA.
Matthew J GieferSeattle Children's Hospital, Seattle, WA, USA.
Praveen GodayMedical College of Wisconsin, Milwaukee, WI, USA.
Tanja GonskaHospital for Sick Children, Toronto, ON, Canada.
Melvin B HeymanUniversity of California San Francisco, San Francisco, CA, USA.
Sohail Z HusainStanford University, Palo Alto, CA, USA.
Tom K LinCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Quin Y LiuCedars-Sinai Medical Center, Los Angeles, CA, USA.
Maria R MascarenhasChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Asim MaqboolChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Brian McFerronRiley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
Veronique D MorinvilleMontreal Children's Hospital, McGill University, Montreal, QC, Canada.
Jaimie D NathanCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Chee Y OoiSchool of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick Sydney, Australia.
Emily R PeritoUniversity of California San Francisco, San Francisco, CA, USA.
John F PohlUniversity of Utah, Salt Lake City, UT, USA.
Sarah Jane SchwarzenbergUniversity of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
Zachary M SellersStanford University, Palo Alto, CA, USA.
Jose SerranoDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, USA.
Uzma ShahMassachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA.
David TroendleUniversity of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
Yuhua ZhengChildren's Hospital Los Angeles, Los Angeles, CA, USA.
Ying YuanThe University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Mark LoweWashington University School of Medicine, Iowa City, IA, USA.
Aliye UcUniversity of Iowa, Stead Family Children's Hospital, Iowa City, IA, USA.
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer
Seattle Children's Hospital · USUniversity of Minnesota Children's Hospital · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USUniversity of California, San Francisco · USBaylor College of Medicine · USCedars-Sinai Medical Center · USChildren's Hospital of Los Angeles · USChildren's Hospital of Pittsburgh · USHarvard University · USHospital for Sick Children · CAIndiana University – Purdue University Indianapolis · USMedical College of Wisconsin · USMontreal Children's Hospital · CANational Institute of Diabetes and Digestive and Kidney Diseases · USNationwide Children's Hospital · USPalo Alto University · USStanford University · USSydney Children's Hospital · AUThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic PancreatitisR01DK118752 · NIDDK · UNIVERSITY OF IOWA · PI PALERMO, TONYA M, UC, ALIYE · 2018 to 2022
$3.0M
Long-Term Developmental and Health Impact of Adolescent Chronic PainF32HD097807 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI MURRAY, CAITLIN · 2019 to 2020
$132k
NCI NIH HHS P30 CA016672NICHD NIH HHS F32 HD097807NIDDK NIH HHS P30 DK054759NIDDK NIH HHS R01 DK118752NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

introductionAbdominal pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of pain in ARP/CP and the efficacy of psychological therapies for other centralized pain syndromes, no studies have evaluated psychological pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the efficacy of a psychological pain intervention for pediatric ARP/CP, and 2) examine baseline patient-specific genetic, clinical, and psychosocial characteristics that may predict or moderate treatment response.

methodsThis single-blinded randomized placebo-controlled multicenter trial aims to enroll 260 youth (ages 10-18) with ARP/CP and their parents from twenty-one INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) centers. Participants will be randomly assigned to either a web-based cognitive behavioral pain management intervention (Web-based Management of Adolescent Pain Chronic Pancreatitis; WebMAP; N = 130) or to a web-based pain education program (WebED; N = 130). Assessments will be completed at baseline (T1), immediately after completion of the intervention (T2) and at 6 months post-intervention (T3). The primary study outcome is abdominal pain severity. Secondary outcomes include pain-related disability, pain interference, health-related quality of life, emotional distress, impact of pain, opioid use, and healthcare utilization.

conclusionsThis is the first clinical trial to evaluate the efficacy of a psychological pain intervention for children with CP for reduction of abdominal pain and improvement of health-related quality of life. Findings will inform delivery of web-based pain management and potentially identify patient-specific biological and psychosocial factors associated with favorable response to therapy. Clinical Trial Registration #: NCT03707431.

Indexed as

Internet-Based InterventionAbdominal PainAdolescentAnalgesics, OpioidChildCognitive Behavioral TherapyHumansMulticenter Studies as TopicPain ManagementPain MeasurementPancreatitisPancreatitis, ChronicQuality of LifeRandomized Controlled Trials as TopicRecurrenceAnalgesics, OpioidAcute recurrent pancreatitisChildrenChronic pancreatitisCognitive-behavioral therapyInternet interventionPain

Identifiers

PMID31756383
PMCPMC6952537
OpenAlexW2990548197

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.