ReviewJournal of speech, language, and hearing research : JSLHR2019
Neuroplasticity in Aphasia: A Proposed Framework of Language Recovery.
Review in Journal of speech, language, and hearing research : JSLHR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Transcranial Magnetic Stimulation Combined With Multimodality Aphasia Therapy for Chronic Poststroke Aphasia: A Randomized Clinical Trial.Neurology · 2025Trial
- Microstructural properties in subacute aphasia: concurrent and prospective relationships underpinning recovery.Brain structure & function · 2024Trial
- Trial
- Improved naming in patients with Broca's aphasia with tDCS.Journal of neurology, neurosurgery, and psychiatry · 2024Trial
- The Impact of Anodal tDCS on Verbal and Nonverbal Functional Communication in Subacute Aphasia-An Observational Study.Brain sciences · 2026Article
- Aphasia severity mediates the relationship between attention and sentence comprehension.Aphasiology · 2026Article
- Transcranial Alternating Current Stimulation as an Adjuvant for Nonfluent Aphasia: A Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2026Article
- Predicting Post-Stroke Aphasia Speech Performance from Multimodal Data with Explainable Machine Learning.bioRxiv : the preprint server for biology · 2026Article
- Cortical hierarchy and aphasia severity: the sensorimotor-association gradient modulates lesion effects within language-specific networks.Communications biology · 2026Article
- Charting the Course of Aphasia Recovery: Factors, Trajectories, and Outcomes.Annual review of linguistics · 2025Article
- Early subacute frontal callosal microstructure and language outcomes after stroke.Brain communications · 2025Article
- The impact of brain-derived neurotrophic factor gene polymorphisms on post-stroke naming in aphasia.PloS one · 2025Article
- Individualized connectomic tACS immediately improves oscillatory network with language facilitation in post-stroke aphasia: a feasibility study of a dysfunctome-based targeting approach.Frontiers in computational neuroscience · 2025Article
- Distinct brain morphometry patterns revealed by deep learning improve prediction of post-stroke aphasia severity.Communications medicine · 2024Article
- Remapping and Reconnecting the Language Network after Stroke.Brain sciences · 2024Review
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Resting-state brain network connectivity is an independent predictor of responsiveness to language therapy in chronic post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Insights gained over 60 years on factors shaping post-stroke aphasia recovery: A commentary on Vignolo (1964).Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Patient With Crossed Aphasia Undergoing Long-Term Speech Therapy: A Case Report.Brain & NeuroRehabilitation · 2023Article
- Cerebral Small Vessel Disease Burden: An Independent Biomarker for Anomia Treatment Responsiveness in Chronic Stroke Patients With Aphasia.Archives of physical medicine and rehabilitation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Purpose Despite a tremendous amount of research in this topic, the precise neural mechanisms underlying language recovery remain unclear. Much of the evidence suggests that activation of remaining left-hemisphere tissue, including perilesional areas, is linked to the best treatment outcomes, yet recruitment of the right hemisphere for various language tasks has also been linked to favorable behavioral outcomes. In this review article, we propose a framework of language recovery that incorporates a network-based view of the brain regions involved in recovery. Method We review evidence from the extant literature and work from our own laboratory to identify findings consistent with our proposed framework and identify gaps in our current knowledge. Results Expanding on Heiss and Thiel's (2006) hierarchy of language recovery, we identify 4 emerging themes: (a) Several bilateral regions constitute a network engaged in language recovery; (b) spared left-hemisphere regions are important components of the network engaged in language recovery; (c) as damage increases in the left hemisphere, activation expands to the right hemisphere and domain-general regions; and (d) patients with efficient, control-like network topology show greater improvement than patients with abnormal topology. We propose a mechanistic model of language recovery that accounts for individual differences in behavior, network topology, and treatment responsiveness. Conclusion Continued work in this topic will lead us to a better understanding of the mechanisms underlying language recovery, biomarkers that influence recovery, and, consequently, more personalized treatment options for individual patients. Presentation Video https://doi.org/10.23641/asha.10257590.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.