ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Association Between Medications Acting on the Central Nervous System and Fall-Related Injuries in Community-Dwelling Older Adults: A New User Cohort Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Drug Therapy and Risk of Incident Frailty: A Systematic Review.Annals of geriatric medicine and research · 2024Pooled it
- Reducing Central Nervous System-Active Medications to Prevent Falls and Injuries Among Older Adults: A Cluster Randomized Clinical Trial.JAMA network open · 2024Trial
- Population aging and divergent burden trajectories of fall-related spinal cord injury: a cross national analysis.International journal of public health · 2026Article
- Network analysis as a tool to illustrate the population-level complex prescribing to community-dwelling people living with dementia.International journal of population data science · 2026Article
- Deprescribing considerations for central nervous system-active polypharmacy in patients with dementia.Journal of the American Geriatrics Society · 2025Article
- Clinician contributions to central nervous system-active polypharmacy among older adults with dementia in the United States.Journal of the American Geriatrics Society · 2025Article
- Innovations in pharmacovigilance studies of medicines in older people.British journal of clinical pharmacology · 2025Review
- Prevalence of central nervous system-active polypharmacy in a cohort of older adults in Argentina.BJPsych open · 2024Article
- Central nervous system medication use around hospitalization.Journal of the American Geriatrics Society · 2024Article
- Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing.Drugs & aging · 2023Article
- Managing Drug-Drug Interactions in Older Adults.Journal of clinical pharmacology · 2023Article
- Prescription characteristics associated with fall-related injury risk among older adults prescribed benzodiazepines: a cohort study.BMC geriatrics · 2022Article
- Pharmacist interventions to deprescribe opioids and benzodiazepines in older adults: A rapid review.Research in social & administrative pharmacy : RSAP · 2022Review
- Article
- Change in central nervous system-active medication use following fall-related injury in older adults.Journal of the American Geriatrics Society · 2022Article
- Pre-injury dispensing of psychoactive prescription drugs in a ten years trauma population: a retrospective registry analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- Prevalence of Central Nervous System-Active Polypharmacy Among Older Adults With Dementia in the US.JAMA · 2021Article
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundIt is well established that individual medications that affect the central nervous system (CNS) increase falls risk in older adults. However, less is known about risks associated with taking multiple CNS-active medications.
methodsEmploying a new user design, we used data from the Adult Changes in Thought study, a prospective cohort of community-dwelling people aged 65 and older without dementia. We created a time-varying composite measure of CNS-active medication exposure from electronic pharmacy fill data and categorized into mutually exclusive categories: current (within prior 30 days), recent (31-90 days), past (91-365 days), or nonuse (no exposure in prior year). We calculated standardized daily dose and identified new initiation. Cox proportional hazards models examined the associations between exposures and the outcome of fall-related injury identified from health plan electronic databases.
resultsTwo thousand five hundred ninety-five people had 624 fall-related injuries over 15,531 person-years of follow-up. Relative to nonuse, fall-related injury risk was significantly greater for current use of CNS-active medication (hazard ratio [HR] = 1.95; 95% CI = 1.57-2.42), but not for recent or past use. Among current users, increased risk was noted with all doses. Risk was increased for new initiation compared with no current use (HR = 2.81; 95% CI = 2.09-3.78). Post hoc analyses revealed that risk was especially elevated with new initiation of opioids.
conclusionsWe found that current use, especially new initiation, of CNS-active medications was associated with fall-related injury in community-dwelling older adults. Increased risk was noted with all dose categories. Risk was particularly increased with new initiation of opioids.
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