Evidence map›Paper›PMID 31755596›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Versatile Bispidine-Based Bifunctional Chelators for

Garima Singh, Kristof Zarschler, Sebastian Hunoldt, Irma Ivette Santana Martínez, Carmen L Ruehl, Madlen Matterna, Ralf Bergmann, Domokos Máthé, Nikolett Hegedüs, Michael Bachmann and 2 more

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. It's a match: use of the radionuclide theranostic pairEJNMMI radiopharmacy and chemistry · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Versatile Bispidine-Based Bifunctional Chelators forChemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Garima SinghHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.ORCID http://orcid.org/0000-0003-1950-8595
Kristof ZarschlerHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.ORCID http://orcid.org/0000-0002-7571-4732
Sebastian HunoldtHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.
Irma Ivette Santana MartínezHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.
Carmen L RuehlAnorganisch-Chemisches Institut INF 270, Universität Heidelberg, 69120, Heidelberg, Germany.
Madlen MatternaHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.
Ralf BergmannHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.ORCID http://orcid.org/0000-0002-8733-4286
Domokos MáthéDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094, Budapest, Hungary.ORCID http://orcid.org/0000-0001-7343-0413
Nikolett HegedüsDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094, Budapest, Hungary.
Michael BachmannHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.
Peter CombaAnorganisch-Chemisches Institut INF 270, Universität Heidelberg, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7796-3532
Holger StephanHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328, Dresden, Germany.ORCID http://orcid.org/0000-0002-2972-2803

Funding

Helmholtz-Gemeinschaft VH-VI-421
6 · The paper itself

Abstract

Bifunctional chelators as parts of modular metal-based radiopharmaceuticals are responsible for stable complexation of the radiometal ion and for covalent linkage between the complex and the targeting vector. To avoid loss of complex stability, the bioconjugation strategy should not interfere with the radiometal chelation by occupying coordinating groups. The C9 position of the very stable Cu

Indexed as

AnimalsBridged Bicyclo Compounds, HeterocyclicCell Line, TumorCetuximabChelating AgentsCoordination ComplexesCopperCycloaddition ReactionHumansMiceMicroscopy, FluorescenceNeoplasmsPositron-Emission TomographyRadiopharmaceuticalsTransplantation, HeterologousbispidineBridged Bicyclo Compounds, HeterocyclicCetuximabChelating AgentsCoordination ComplexesCopperRadiopharmaceuticalsbifunctional chelatorsbispidinesEGFRimagingsite-specific labelling

Identifiers

PMID31755596
PMCPMC7028042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.