Evidence map›Paper›PMID 31755223›Full record

ArticleCancer medicine2020

Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort.

Cynthia B de Medeiros, Iska Moxon-Emre, Nadia Scantlebury, David Malkin, Vijay Ramaswamy, Alexandra Decker, Nicole Law, Toshihiro Kumabe, Jeffrey Leonard, Josh Rubin and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Quality of life in survivors of pediatric medulloblastoma: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 6 countries.

Cynthia B de MedeirosDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0003-4997-1994
Iska Moxon-EmreDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.
Nadia ScantleburyNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
David MalkinDepartment of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Vijay RamaswamyDepartment of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Alexandra DeckerNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Nicole LawDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.
Toshihiro KumabeTohoku University Graduate School of Medicine, Sendai, Japan.
Jeffrey LeonardNationwide Children's Hospital, Columbus, OH, USA.
Josh RubinSt. Louis Children's Hospital, St. Louis, MO, USA.
Shin JungChonnam National University, Hwasun-gun, Korea.
Seung-Ki KimSeoul National University Hospital, Seoul, Korea.
Nalin GuptaUniversity of California San Francisco, San Francisco, CA, USA.
William WeissUniversity of California San Francisco, San Francisco, CA, USA.
Claudia C FariaHospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
Rajeev VibhakarUniversity of Colorado Denver, Aurora, CO, USA.
Lucie Lafay-CousinAlberta Children's Hospital, Calgary, AB, Canada.
Jennifer ChanAlberta Children's Hospital, Calgary, AB, Canada.
Johan M KrosErasmus Medical Center, Rotterdam, The Netherlands.
Laura JanzenDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.
Michael D TaylorDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Eric BouffetDepartment of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Donald J MabbottDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-6161-5066
University of Toronto · CAHospital for Sick Children · CAUniversity of Calgary · CAUniversity of California, San Francisco · USCentro Hospitalar Lisboa Norte · PTChonnam National University Hwasun Hospital · KRErasmus MC · NLNationwide Children's Hospital · USPediatric Oncology Group · CASeoul National University Hospital · KRSt. Louis Children's Hospital · USTohoku University · JPUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnderstanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an international cohort of pediatric medulloblastoma patients.

methodsSeventy-six patients were selected from 10 sites across North America, Europe, and Asia, who participated in the Medulloblastoma Advanced Genomics International Consortium (MAGIC). The Health Utilities Index (HUI) was administered to patients and/or parents at each site. Responses were used to determine overall HRQL and attributes (ie specific subdomains). The impact of various demographic and medical variables on HRQL was considered-including molecular subgroup.

resultsThe majority of patients reported having moderate or severe overall burden of morbidity for both the HUI2 and HUI3 (HUI2 = 60%; HUI3 = 72.1%) when proxy-assessed. Self-care in the HUI2 was rated as higher (ie better outcome) for patients from Western versus Eastern sites, P = .02. Patients with nonmetastatic status had higher values (ie better outcomes) for the HUI3 hearing, HUI3 pain, and HUI2 pain, all P < .05. Patients treated with a gross total resection also had better outcomes for the HUI3 hearing (P = .04). However, those who underwent a gross total resection reported having worse outcomes on the HUI3 vision (P = .02). No differences in HRQL were evident as a function of subgroup.

conclusionsBy examining an international sample of survivors, we characterized the worldwide impact of medulloblastoma. This is a critical first step in developing global standards for evaluating long-term outcomes.

Indexed as

Quality of LifeAdolescentAntineoplastic Combined Chemotherapy ProtocolsCancer SurvivorsCerebellar NeoplasmsChildChild, PreschoolCohort StudiesCombined Modality TherapyCraniospinal IrradiationFemaleFollow-Up StudiesGlobal HealthHealth StatusHumansInfantdevelopmentmedulloblastomapediatric psychologyquality of lifesurvivors of childhood cancer

Identifiers

PMID31755223
PMCPMC6970040
OpenAlexW2991296391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.