Evidence map›Paper›PMID 31755189›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Model-Based Nanoengineered Pharmacokinetics of Iron-Doped Copper Oxide for Nanomedical Applications.

Hendrik Naatz, Bella B Manshian, Carla Rios Luci, Vasiliki Tsikourkitoudi, Yiannis Deligiannakis, Johannes Birkenstock, Suman Pokhrel, Lutz Mädler, Stefaan J Soenen

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Quantitative In Situ Monitoring of Cu-Atom Release by CuNanomaterials (Basel, Switzerland) · 2023
    Article
  10. Cu-doped TiOJournal of nanobiotechnology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. The Role of Optical Imaging in Translational Nanomedicine.Journal of functional biomaterials · 2022
    Review
  15. Article
  16. Article
  17. Double Flame-Fabricated High-Performance AlPOACS applied energy materials · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Hendrik NaatzUniversity of Bremen, Faculty of Production Engineering, Badgasteiner Str. 1, 28359, Bremen, Germany.ORCID 0000-0002-2188-2167
Bella B ManshianNanoHealth and Optical Imaging Group, KU Leuven, Department of Imaging and Pathology, Belgium.ORCID 0000-0002-3402-3927
Carla Rios LuciNanoHealth and Optical Imaging Group, KU Leuven, Department of Imaging and Pathology, Belgium.ORCID 0000-0001-8636-1509
Vasiliki TsikourkitoudiUniversity of Ioannina, Department of Physics, Panepistimioupoli Douroutis, 445110, Ioannina, Greece.ORCID 0000-0003-0820-3585
Yiannis DeligiannakisUniversity of Ioannina, Department of Physics, Panepistimioupoli Douroutis, 445110, Ioannina, Greece.ORCID 0000-0002-9390-4222
Johannes BirkenstockCentral Laboratory for Crystallography and Applied Materials, University of Bremen, 28359, Bremen, Germany.
Suman PokhrelUniversity of Bremen, Faculty of Production Engineering, Badgasteiner Str. 1, 28359, Bremen, Germany.ORCID 0000-0001-5712-2824
Lutz MädlerUniversity of Bremen, Faculty of Production Engineering, Badgasteiner Str. 1, 28359, Bremen, Germany.ORCID 0000-0002-7073-0733
Stefaan J SoenenNanoHealth and Optical Imaging Group, KU Leuven, Department of Imaging and Pathology, Belgium.ORCID 0000-0003-2390-3133
University of Bremen · DEKU Leuven · BEUniversity of Ioannina · GR

Funding

Predictive Toxicological Paradigm for Chronic Nanoparticle Injury in the LungR01ES016746 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2008 to 2017
$3.4M
Deutsche Forschungsgemeinschaft MA3333/13-1Deutsche Forschungsgemeinschaft MA3333/16-1Fonds Wetenschappelijk onderzoek Vlaanderen G0B2919NFWO research projectsHorizon 2020 ERC StG 750973Horizon 2020 ERC ERC StG 757398KU Leuven IF C2KU Leuven IF C2 3M180306NIEHS NIH HHS R01 ES016746
6 · The paper itself

Abstract

The progress in nanomedicine (NM) using nanoparticles (NPs) is mainly based on drug carriers for the delivery of classical chemotherapeutics. As low NM delivery rates limit therapeutic efficacy, an entirely different approach was investigated. A homologous series of engineered CuO NPs was designed for dual purposes (carrier and drug) with a direct chemical composition-biological functionality relationship. Model-based dissolution kinetics of CuO NPs in the cellular interior at post-exposure conditions were controlled through Fe-doping for intra/extra cellular Cu

Indexed as

CopperHumansMetal NanoparticlesNanomedicineNanotechnologyOxidesCopperOxidescontrolled pharmacokineticscopper oxidenanomedicinenanoparticlesstructure-release models

Identifiers

PMID31755189
PMCPMC7004194
OpenAlexW2990934069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.