ArticleEpilepsia2019
Segregation of seizures and spreading depolarization across cortical layers.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multifocal Initiation of Spreading Depolarization by Generalized Tonic-Clonic Seizures.International journal of molecular sciences · 2026Article
- Dual role of spreading depolarization in an epileptic focus.Epilepsia · 2026Article
- Article
- Review
- BETMB: A Dual-Target Compound for Synergistic Suppression of Neuronal Hyperexcitability in Refractory Epilepsy via Concurrent Modulation of Nav Channels and GABACNS neuroscience & therapeutics · 2026Article
- Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations.Neurobiology of disease · 2025Article
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
- Contralesional hippocampal spreading depolarization promotes functional recovery after stroke.Nature communications · 2025Article
- Progesterone receptors regulate susceptibility to spreading depression.Experimental neurology · 2025Article
- Characterization of spreading depolarizations in swine following superior sagittal sinus occlusion: a novel gyrencephalic model study.Thrombosis journal · 2025Article
- Chronic Hyperhomocysteinemia Impairs CSD Propagation and Induces Cortical Damage in a Rat Model of Migraine with Aura.Biomolecules · 2024Article
- Differential cortical layer engagement during seizure initiation and spread in humans.Nature communications · 2024Article
- Altered functional connectivity after pilocarpine-induced seizures revealed by intrinsic optical signals imaging in awake mice.Neurophotonics · 2024Article
- Diversity of cortical activity changes beyond depression during Spreading Depolarizations.Nature communications · 2023Article
- Comparative Study of Terminal Cortical Potentials Using Iridium and Ag/AgCl Electrodes.International journal of molecular sciences · 2023Article
- Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures.Neurocritical care · 2022Article
- Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes.Nature nanotechnology · 2022Article
- Headache in people with epilepsy.Nature reviews. Neurology · 2021Review
- Spreading depression as an innate antiseizure mechanism.Nature communications · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveCortical spreading depolarization (SD) and seizures are often co-occurring electrophysiological phenomena. However, the cross-layer dynamics of SD during seizures and the effect of SD on epileptic activity across cortical layers remain largely unknown.
methodsWe explored the spatial-temporal dynamics of SD and epileptic activity across layers of the rat barrel cortex using direct current silicone probe recordings during flurothyl-induced seizures.
resultsSD occurred in half of the flurothyl-evoked seizures. SD always started from the superficial layers and spread downward either through all cortical layers or stopping at the L4/L5 border. In cases without SD, seizures were characterized by synchronized population firing across all cortical layers throughout the entire seizure. However, when SD occurred, epileptic activity was transiently silenced in layers involved with SD but persisted in deeper layers. During partial SD, epileptiform activity persisted in deep layers throughout the entire seizure, with positive signals at the cortical surface reflecting passive sources of population spikes generated in deeper cortical layers. During full SD, the initial phase of SD propagation through the superficial layers was similar to partial SD, with suppression of activity at the superficial layers and segregation of seizures to deep layers. Further propagation of SD to deep layers resulted in a wave of transient suppression of epileptic activity through the entire cortical column. Thus, vertical propagation of SD through the cortical column creates dynamic network states during which epileptiform activity is restricted to layers without SD. SIGNIFICANCE: Our results point to the importance of vertical SD spread in the SD-related depression of epileptiform activity across cortical layers.
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