Evidence map›Paper›PMID 31755104›Full record

ReviewJournal of neurochemistry2020

Neurochemical organization of the ventral striatum's olfactory tubercle.

Hillary L Cansler, Katherine N Wright, Lucas A Stetzik, Daniel W Wesson

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neurochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
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  4. A midbrain-to-ventral-striatum dopaminergic pathway orchestrates odor-guided insect predation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Article
  8. Article
  9. Review
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  11. Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
  12. Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hillary L CanslerDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8267-0515
Katherine N WrightDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-3514-8414
Lucas A StetzikDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Daniel W WessonDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-3192-3866
University of Florida · US

Funding

Striatal mechanisms for e-cigarette reinforcement by flavorantsR01DA049545 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DE BIASI, MARIELLA, MA, MINGHONG · 2019 to 2023
$3.2M
Linking Synucleinopathy and Dysfunction of Olfactory PathwaysR01DC016519 · NIDCD · VAN ANDEL RESEARCH INSTITUTE · PI MOORE, DARREN JOHN, WESSON, DANIEL W · 2017 to 2021
$2.8M
INTER-REGIONAL CODING OF ODOR VALENCE BY NEURAL ENSEMBLESR01DC014443 · NIDCD · UNIVERSITY OF FLORIDA · PI WESSON, DANIEL W · 2015 to 2019
$2.3M
Circuitry and function of ventral striatum subregionsR01DA049449 · NIDA · UNIVERSITY OF FLORIDA · PI MA, MINGHONG, WESSON, DANIEL W · 2020 to 2024
$2.1M
Odor-directed attention and the medial prefrontal cortexF32DC018232 · NIDCD · UNIVERSITY OF FLORIDA · PI CANSLER, HILLARY LAUREN · 2019 to 2021
$195k
NIDA NIH HHS R01 DA049449NIDA NIH HHS R01 DA049545NIDCD NIH HHS F32 DC018232NIDCD NIH HHS R01 DC014443NIDCD NIH HHS R01 DC016519
6 · The paper itself

Abstract

The ventral striatum is a collection of brain structures, including the nucleus accumbens, ventral pallidum and the olfactory tubercle (OT). While much attention has been devoted to the nucleus accumbens, a comprehensive understanding of the ventral striatum and its contributions to neurological diseases requires an appreciation for the complex neurochemical makeup of the ventral striatum's other components. This review summarizes the rich neurochemical composition of the OT, including the neurotransmitters, neuromodulators and hormones present. We also address the receptors and transporters involved in each system as well as their putative functional roles. Finally, we end with briefly reviewing select literature regarding neurochemical changes in the OT in the context of neurological disorders, specifically neurodegenerative disorders. By overviewing the vast literature on the neurochemical composition of the OT, this review will serve to aid future research into the neurobiology of the ventral striatum.

Indexed as

Olfactory TubercleAnimalsHumansVentral StriatumacetylcholinebehaviordementiadopamineGABAmotivationneurodegenerationParkinson's disesaesensorystriatum

Identifiers

PMID31755104
PMCPMC7042089
OpenAlexW2991650076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.