ArticleJournal of the American Society for Mass Spectrometry2019
A First Principle Model of Differential Ion Mobility: the Effect of Ion-Solvent Clustering.
Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Exploring Field-Induced Fragmentation of Protonated Alcohols: Mechanistic Insights and Stabilizing Ion-Solvent Clusters.Journal of the American Society for Mass Spectrometry · 2026Article
- Sensitivity vs Competing Proton Transfer Reactions: Addressing Key Parameters of Ion Chemistry in Ion Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2025Article
- Determination of Collisional Cross Section Using Microscale High-Field Asymmetric Waveform ion Mobility Spectroscopy-Mass Spectrometry (FAIMS-MS).Rapid communications in mass spectrometry : RCM · 2025Article
- Reliable Detection of Chemical Warfare Agents Using High Kinetic Energy Ion Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2024Article
- On the Arrival Time Distribution of Reacting Systems in Ion Mobility Spectrometry.Analytical chemistry · 2024Article
- Non-destructive method to classify walnut kernel freshness from volatile organic compound (VOC) emissions using gas chromatography-differential mobility spectrometry (GC-DMS) and machine learning analysis.Applied food research · 2023Article
- Separating chiral isomers of amphetamine and methamphetamine using chemical derivatization and differential mobility spectrometry.Analytical science advances · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The use of differential mobility spectrometry (DMS) as a separation tool prior to mass analysis has increased in popularity over the years. However, the fundamental principles behind the difference between high- and low-field mobility is still a matter of debate-especially regarding the strong impact of solvent molecules added to the gas phase in chemically modified DMS environments. In this contribution, we aim to present a thorough model for the determination of the ion mobility over a wide range of field strengths and subsequent calculation of DMS dispersion plots. Our model relies on first principle calculations only, incorporating the modeling of the "hard-sphere" mobility, the change in CCS with field strength, and the degree of clustering of solvent molecules to the ion. We show that all three factors have to be taken into account to qualitatively predict dispersion plots. In particular, type A behavior (i.e., strong clustering) in DMS can only be explained by a significant change of the mean cluster size with field strengths. The fact that our model correctly predicts trends between differently strong binding solvents, as well as the solvent concentration and the background gas temperature, highlights the importance of clustering for differential mobility.
Indexed as
Identifiers
31755046What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.