Evidence map›Paper›PMID 31754993›Full record

ArticleDigestive diseases and sciences2020

Breath Test Gas Patterns in Inflammatory Bowel Disease with Concomitant Irritable Bowel Syndrome-Like Symptoms: A Controlled Large-Scale Database Linkage Analysis.

Phillip Gu, Devin Patel, Krutika Lakhoo, Jeffrey Ko, Xiaochen Liu, Bianca Chang, Dana Pan, Greg Lentz, Matthew Sonesen, Renier Estiandan and 3 more

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Phillip GuDivision of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, TX, USA. phillipgu12@gmail.com.
Devin PatelDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Krutika LakhooDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jeffrey KoDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Xiaochen LiuDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Bianca ChangSection of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, IL, USA.
Dana PanDivision of Gastroenterology and Hepatology, University of California in Davis, Sacramento, CA, USA.
Greg LentzEnterprise Information Services- Initiate Team, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Matthew SonesenEnterprise Information Services- Initiate Team, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Renier EstiandanEnterprise Information Services- Initiate Team, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Eugenia LinDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mark PimentelDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ali RezaieDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of California, Davis · USUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBreath testing (BT) has gained interest for diagnosing small intestinal bacterial overgrowth (SIBO) in IBD patients with irritable bowel syndrome (IBS) overlap. We aim to characterize the rate of SIBO and BT gas patterns in IBD patients with IBS-like symptoms compared to non-IBD patients.

methodsA database of 14,847 consecutive lactulose BTs was developed from patients with IBS-like symptoms between November 2005 and October 2013. BTs were classified as normal, H

resultsAfter excluding patients with repeat breath tests, we identified 486 IBD and 10,505 non-IBD patients with at least one BT. Positive BT was present in 57% (n = 264) of IBD patients. Crohn's disease (odds ratio (OR) 0.21, [95% confidence interval (CI) 0.11-0.38]) and ulcerative colitis (OR 0.39, [95% CI 0.22-0.70]) patients were less likely to produce excess CH

conclusionIn a cohort of IBD patients with IBS-like symptoms, a high rate of patients had positive BT and symptomatic improvement with antibiotics. In IBD, methanogenesis is suppressed and flatline BT is more frequent, suggesting excess hydrogenotrophic bacteria. These findings suggest methanogenic and hydrogenotrophic microorganisms as potential targets for microbiome-driven biomarkers and therapies.

Indexed as

AdultAgedAnti-Bacterial AgentsBreath TestsCross-Sectional StudiesDysbiosisFemaleHumansInflammatory Bowel DiseasesIrritable Bowel SyndromeMaleMiddle AgedRetrospective StudiesAnti-Bacterial AgentsBreath testCrohn’s diseaseInflammatory bowel diseaseSmall intestinal bacterial overgrowthUlcerative colitis

Identifiers

PMID31754993
OpenAlexW2991399486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.