ArticleDigestive diseases and sciences2020
Corticosteroid Treatment at Diagnosis: An Analysis of Relapses, Disease Extension, and Colectomy Rate in Ulcerative Colitis.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Corticosteroid-sparing effects of risankizumab efficacy and safety in patients with moderately to severely active ulcerative colitis.Journal of Crohn's & colitis · 2025Trial
- Initial Treatment Failure as a Predictor of Proximal Extension in Patients with Newly Diagnosed Limited Ulcerative Colitis: A Retrospective Cohort Study with Propensity Score-Matched Analysis.Digestive diseases and sciences · 2026Article
- Costunolide and dehydrocostus lactone alleviate ulcerative colitis via regulating TLR4, NF-κB and PI3K expression.Scientific reports · 2024Article
- Combined Administration of Vitamin DFrontiers in pharmacology · 2021Article
- Relationship between mucosal healing by tacrolimus and relapse of refractory ulcerative colitis: a retrospective study.BMC gastroenterology · 2020Article
- Fecal Calprotectin Predicts Mucosal Healing in Patients With Ulcerative Colitis Treated With Biological Therapies: A Prospective Study.Clinical and translational gastroenterology · 2020Observational
- A Retrospective Observational Study of Patterns of Biologic Drug Change in Inflammatory Bowel Disease.Inflammatory intestinal diseasesArticle
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis is a chronic relapsing disease usually treated with mesalamine. The need of steroid therapy at diagnosis is generally considered as a poor prognostic factor.
aimsThe aim of our study was to assess whether patients treated with corticosteroids at diagnosis have more clinical relapses, disease progression, or an increased risk of colectomy during a 5-year follow-up.
methodsWe retrospectively evaluated patients who had received diagnosis of ulcerative colitis with a 5-year follow-up. Relapse was defined as a worsening of symptoms requiring an increase in medical treatment. Progression of disease was defined as a proximal extension of mucosal involvement, comparing the colonoscopy performed 5 years after diagnosis with the first one. The need of corticosteroid treatment at diagnosis was correlated to number of relapses, disease progression, and colectomy rate.
resultsWe included 230 patients, 116 of them (50%) treated with steroids at diagnosis. Multivariate analysis demonstrated that there is a strong correlation between corticosteroid use and number of relapses (p < 0.01), as well as with disease progression (p < 0.05). Seventeen patients (7.4%) underwent colectomy, but the correlation with steroids was not statistically significant.
conclusionsThese data provide evidence that the need of corticosteroids at diagnosis is associated with a worse clinical outcome.
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